A Retrospective study on Adverse Drug Reactions Monitoring and Reporting in a quaternary care super speciality hospital in Karnataka (original) (raw)

Asian Journal of Pharmacy and Pharmacology

Background The World Health Organization defines a "adverse drug reaction," which has been in use for about 30 years, as "a response to a drug that is toxic and unexpected and occurs at levels commonly employed in man for the prevention, diagnosis, or treatment of disease, or for altering physiological function." ADRs should be carefully considered and managed right away in order to shield patients from undesirable pharmacological side effects. Objective: To evaluate the degree of association between suspected ADR and pharmacological therapy, the WHO Probability assessment scale was applied. To establish the causative link between a drug and a suspected reaction, the Naranjo's causality assessment scale was applied. Methodology: The study was carried out at a quaternary care super speciality hospital. The study was carried out for a period of 2 month where the previous ADR reported forms were considered for the review from the year 2019-2022. A total 106 ADR are reported from 2019 to 2021 in Results: quaternary super speciality hospital in southern India. Among that majority were females 51.9% and males are 48.1%, maximum number of ADRs were reported from the general medicine 49(46.3%), followed by general surgery 16(15.2%), Orthopaedics 12(11.3%), Neurology 11(10.4%), Nephrology 8(7.5%), Oncology 5(4.7%), Gastroenterology 3(2.8%), Paediatrics 1(0.9%) and Cardiology 1(0.9%). 33% of the population experienced rashes and itching as the ADR. 80.2% of the ADR were minor and all were treated and recovered. The Conclusion: occurrence of adverse events, which raises healthcare expenditures, is influenced by adverse medication responses, which are a major cause of morbidity and mortality. Continuous encouragement is required for ADR reporting. It is crucial to foster a supportive attitude toward pharmacovigilance among medical practitioners, including pharmacists, so that reporting ADRs becomes a common and acknowledged practise.