Triterpenes and Triterpenoids Clinically Useful with Multiple Targets in Cancer, Malaria and More Treatment: Focus on Potential Therapeutic Value (original) (raw)

2017, International Journal of Biochemistry Research & Review

Triterpenoids are the most promising plant secondary metabolites. Several triterpenoids, including ursolic acid, oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol and avicins are representative group of phytochemicals possesses biological properties. Anti-tumor, anti-cancer, antibiotic , cytotoxic, anti-inflammatory, anti-HIV, acetyl cholinesterase, anti-wrinkle and antifeedant activities of these compounds is measured. Role for triterpenes in the cancer setting is also gradually emerging. Triterpenoids are highly multifunctional and structurally diverse organic compounds, characterized by a basic backbone modified in multiple ways, allowing the formation of more than 20,000 naturally occurring triterpenoid varieties. Fusidic acid is a representative member of terpenes, which has found clinical applications. It is nonallergic, has relatively low toxicity and has little cross-resistance with other clinically used antibiotics and it remains a unique and promising agent due to the significant potencies against Staphylococci.