Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study (original) (raw)
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Characteristics of critically ill patients infected with COVID-19 in Abu Dhabi, United Arab Emirates
Anaesthesia Critical Care & Pain Medicine, 2020
, a novel coronavirus SARS-CoV-2 emerged in Wuhan city and extended around the globe. As of June 26, 2020, approximately 46,563 confirmed cases have been documented in the United Arab Emirates (UAE), with 308 deaths [1]. There are no reports describing patients admitted to the intensive care unit (ICU) with COVID-19 in the UAE. This study's primary objective was to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 admitted to the ICU at Cleveland Clinic Abu Dhabi. A retrospective study was conducted for this purpose. A waiver of informed consent was obtained from the Ethics Committee at Cleveland Clinic Abu Dhabi (number: A-2020-035). All consecutive adult patients admitted to our ICU between March 31 and May 10, 2020, with confirmed SARS-CoV-2 infection (virus detected by a real time reverse transcriptase-polymerase chain reaction assay of a nasopharyngeal sample) were included. De-identified data from the electronic medical record were collected: comorbidities, laboratory data at ICU admission, arterial blood gas and respiratory mechanics data on admission and during the first 3 days. Continuous variables are expressed as mean AE SD or as median [interquartile range], and proportions were used for categorical variables. From March 31 to May 10, 2020, 508 adult patients with COVID-19 infection were admitted to the hospital. Among them, 55 patients (11%, 51 males) required ICU admission and were
Medicina, 2021
Backgroundand Objectives: COVID-19 is a novel infectious disease caused by a single-stranded RNA coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to conduct a nationwide multicenter study to determine the characteristics and the clinical prognostic outcome of critically ill COVID-19 patients admitted to intensive care units (ICUs). Materials and Methods: This is a nationwide cohort retrospective study conducted in twenty Saudi hospitals. Results: An analysis of 1470 critically ill COVID-19 patients demonstrated that the majority of patients were male with a mean age of 55.9 ± 15.1 years. Most of our patients presented with a shortness of breath (SOB) (81.3%), followed by a fever (73.7%) and a cough (65.1%). Diabetes and hypertension were the most common comorbidities in the study (52.4% and 46.0%, respectively). Multiple complications were observed substantially more among non-survivors. The length and frequency of mechanical ventilation use ...
Travel Medicine and Infectious Disease, 2021
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The COVID-19 pandemic had caused significant morbidity and mortality, with over a million deaths recorded to date. Mortality recorded among severe-critically ill patients admitted to intensive care units (ICU) has been significantly high, especially in most COVID-19 epicenters. Reports on the unique clinical characteristics and outcomes from the ICU admissions are on-going with isolated studies in Africa. This study was a retrospective single-centre study involving all polymerase chain reaction (PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients admitted to the medical intensive care unit (MICU) of the department of medicine and therapeutics, Korle-Bu Teaching Hospital, over the period of 13th April - 28th June 2020. Twenty-two (22) patients in total fulfilled the inclusion criteria and are included in this report. Patients' socio-demographic characteristics, clinical and laboratory parameters outcomes as well as treatment modalities employed we...
International Journal of General Medicine
Background: A good understanding of the possible risk factors for coronavirus disease 19 (COVID-19) severity could help clinicians in identifying patients who need prioritized treatment to prevent disease progression and adverse outcome. In the present study, we aimed to correlate clinical and laboratory characteristics of hospitalized COVID-19 patients to disease outcome in Saudi Arabia. Materials and Methods: The present study included 199 COVID-19 patients admitted to King Fahd Specialist Hospital, Buraydah, Qassim, Saudi Arabia, from April to December 2020. Patients were followed-up until discharge either for recovery or death. Demographic data, clinical data and laboratory results were retrieved from electronic patient records. Results: Critical COVID-19 cases showed higher mean of age and higher prevalence of co-morbid conditions. Fifty-five patients died during the observation period. Risk factors for in hospital death for COVID 19 patients were leukocytosis (OR 1.89, 95% CI 1.008-3.548, p = 0.081), lymphocytopenia (OR 2.152, 95% CI 1.079-4.295, p = 0.020), neutrophilia (OR 1.839, 95% CI 0.951-3.55, p = 0.047), thrombocytopenia (OR 2.152, 95% CI 0.852-5.430, p = 0.085), liver injury (OR 2.689, 95% CI 1.373-4.944, p = 0.003), acute kidney injury (OR 1.248, 95% CI 0.631-2.467 p = 0.319), pancreatic injury (OR 1.973, 95% CI 0.939-4.144, p = 0.056) and high D dimer (OR 2.635, 95% CI 0.747-9.287, p = 0.091). Conclusion: Clinical and laboratory data of COVID-19 patients may help understanding the pathogenesis of the disease and subsequently improve of the outcome of patients by determination of the associated risk factors and recognition of high risk group who are more liable for complications and in hospital death. The present study put an eye on some parameters (laboratory and clinical) that should be alarming signs that the patient is at high risk bad prognosis.
Journal of Clinical Medicine
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Medical Principles and Practice, 2020
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International Journal of Infectious Diseases, 2021
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ICU outcomes of COVID-19 critically ill patients: An international comparative study
Anaesthesia Critical Care & Pain Medicine, 2020
Coronavirus disease (COVID-19) caused by the new coronavirus SARS-CoV-2 has hit the world as a global pandemic of an unprecedented scale. COVID-19 has become one of the major causes of death worldwide. It is estimated that around 5% of cases are critically ill, requiring intensive care unit (ICU) admission. As of June 29, 2020, United Arab Emirates counts 47,797 cases, with 313 deaths [1]. The observed ICU mortality rate of COVID-19 is highly variable [2-5]. Also, no studies have reported the ICU outcomes of COVID-19 critically ill patients in the United Arab Emirates. The aim was to compare the published ICU case series [2-6], including ours, to understand the reasons for the differences in ICU mortality and if it is related to different ICU management of these patients (different rates of mechanical ventilation). The institutional Ethics Committee of Cleveland Clinic Abu Dhabi approved the study (number: A-2020-035), and a waiver of informed consent was obtained. Series of ICU patients with confirmed COVID-19 infection from published cohorts were included [2-6]. Regarding our study, all consecutive adult patients admitted to our ICU between March 31 and May 10, 2020, with confirmed SARS-CoV-2 infection (virus detected by a real time reverse transcriptase-polymerase chain reaction assay of a nasopharyngeal sample) were included. De-identified data from the electronic medical record were collected. Continuous variables are expressed as mean AE SD or as median [interquartile range], and proportions were used for categorical variables. Five ICU cohorts from four different countries (China, USA, Italy, and Spain) [2-6] were included along with our case series. The mean/median age was comparable between all these reported cohorts (60-64 years) except for our report, which was lower (51 AE 13 years) (Table 1). SOFA score was similar in Atlanta and Vitoria cohorts, but was higher than observed in our study. APACHE II score was comparable between the different reports (Table 1). Mechanical ventilation (MV) rate in our patients was the same as in Seattle and Atlanta reports (75% and 76%, respectively), but higher than in the Wuhan series (42%), and lower than in Lombardy and Vitoria series (89% and 94%, respectively) (Table 1). Prone position rate was comparable in the USA, China, and Italy cohorts ($27%), higher in the Spain report (49%), but much higher in our study (79%). The use of extracorporeal membrane oxygenation (ECMO) was similar in our and Wuhan reports (11%), but much higher than in the other cohorts (Table 1). The mortality rate in Wuhan and Seattle were much higher (61% and 50%, respectively) compared with the other reported ICU cohorts ranging from 26% to 33% (Table 1 and Fig. 1). The mortality rate among patients who required MV was not reported in the