Abstract 2220: PD-L1 expression in primary tumor and circulating tumor cells in patients with small cell lung carcinomas (original) (raw)

Cancer Research, 2016

Abstract

Background: Although small cell lung carcinomas (SCLC) show an initial response to treatment, patients rapidly suffer disease recurrence and become refractory to chemotherapy. Despite intensive research, the prognosis of SCLC remains poor, and therefore new strategies to improve outcome are urgently needed. Blockade of immune checkpoints PD-1/PD-L1 with monoclonal antibodies has recently emerged as a new therapeutic tool in oncology. Due to the difficulty in obtaining adequate tissue in diseases such as SCLC for PD-L1 expression assessment, we investigated the usefulness of circulating tumor cells (CTCs) detection as a non-invasive method to evaluate PD-L1 status in SCLC patients. Materials and Methods: CTC capture and PD-L1 expression was evaluated in a cohort of 18 SCLC patients for whom resected tissue specimens were available and were positive for CTCs, as detected by using the filtration-based ISET platform (Rarecells Diagnostics, Paris, France). PD-L1 expression was evaluated ...

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