Findings of inflammation and possible autoimmunity in calcific aortic stenosis of unknown etiology in the geriatric population (original) (raw)

Senile calcific aortic stenosis (SCAS) is prevalent among the geriatric population, yet its etiology remains obscure. This study investigates the role of inflammation and potential autoimmunity in SCAS by examining stenotic valvular tissues. Findings indicate that activated immune cells are present in SCAS tissues, alongside signs of neovascularization and possible Russell body formation. These results suggest an autoimmune component in SCAS, warranting further research into the immunological responses involved and their implications for non-surgical treatment strategies.