Platelet soluble CD40-ligand level is associated with transfusion adverse reactions in a mixed threshold-and-hit model (original) (raw)

Platelets are a significant source of soluble CD40-ligand (sCD40L), which has been implicated in serious adverse reactions (SARs) following platelet transfusions, such as febrile nonhemolytic reactions and transfusion-related acute lung injury (TRALI). This study evaluated the relationship between elevated sCD40L levels and the incidence of SARs using data from 9206 platelet concentrate transfusions. The analysis indicated that while high levels of sCD40L may be predictive of SARs, not all patients who received these levels experienced adverse reactions, suggesting the presence of additional influencing factors.