Highly constrained bicyclic VLA-4 antagonists (original) (raw)
Discovery of N-{ N-[(3-cyanobenzene) sulfonyl]-4( R)-(3,3-difluoropiperidin-1-yl)-( l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-( l)-phenylalanine (MK-0617), a highly potent and orally active VLA4 antagonist
Shankar Venkatraman
Bioorganic & Medicinal Chemistry Letters, 2009
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Influence of acid surrogates toward potency of VLA4 antagonist
Shankar Venkatraman
Bioorganic & Medicinal Chemistry Letters, 2005
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N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists
Malcolm Maccoss
Bioorganic & Medicinal Chemistry Letters, 2002
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2,6-Quinolinyl derivatives as potent VLA-4 antagonists
Abdoulaye Gassama
Bioorganic & Medicinal Chemistry Letters, 2007
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Arylsulfonamide pyrimidines as VLA-4 antagonists
Elizabeth Messersmith
Bioorganic & Medicinal Chemistry Letters, 2013
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Diamine containing VLA-4 antagonists
Andrew Morley
Bioorganic & Medicinal Chemistry, 2001
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Anti-inflammatory activity of c(ILDV-NH(CH 2 ) 5 CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion
Christopher Reilly
British Journal of Pharmacology, 1999
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The Design and Synthesis of Potent Cyclic Peptide VCAM-VLA-4 Antagonists Incorporating An Achiral Asp-Pro Mimetic
pramod joshi
Bioorganic & medicinal …, 2000
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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA4 antagonists
Quang Truong
Bioorganic & Medicinal Chemistry Letters, 2002
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Discovery of N -{ N -[(3-Cyanophenyl)sulfonyl]-4( R )-cyclobutylamino-( l )-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-( l )-phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4
Malcolm Maccoss
Journal of Medicinal Chemistry, 2009
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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model
Mark Dreyer
Bioorganic & Medicinal Chemistry Letters, 2011
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N-Cycloalkanoyl-l-Phenylalanine Derivatives as VCAM/VLA-4 Antagonists
Achyutharao Sidduri
Bioorganic & Medicinal Chemistry Letters, 2002
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Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists
Thomas Reger
Bioorganic & Medicinal Chemistry Letters, 2010
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Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist
Zahid Hussain
Bioorganic & Medicinal Chemistry Letters, 2005
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Amidines as amide bond replacements in VLA-4 antagonists
Stephen de Laszlo, Malcolm Maccoss
Bioorganic & Medicinal Chemistry Letters, 2004
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Discovery of Very Late Antigen-4 (VLA-4, 4 1 Integrin) Allosteric Antagonists
Alexandre Chigaev
Journal of Biological Chemistry, 2011
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Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: From a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses
Daniele Bellocchi
ChemInform, 2004
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Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists
Dr. Tridib Chaira
Bioorganic & Medicinal Chemistry Letters, 2013
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N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists
Clare Gutteridge
Bioorganic & Medicinal Chemistry Letters, 2003
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Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas
Marla Weetall
Molecular diversity, 2000
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3D QSAR (COMFA) of a series of potent and highly selective VLA4 antagonists
Herman van Vlijmen
Journal of Computer-aided Molecular Design, 2002
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Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma
Hasan Arshad
The Journal of allergy and clinical immunology, 2005
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Squaric acid derivatives as VLA-4 integrin antagonists
Richard Taylor
Bioorganic & Medicinal Chemistry Letters, 2002
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Synthesis of constrained l-phenylalanine derivatives incorporating a benzazepinone or an azepinone ring as VCAM/VLA-4 antagonists
Achyutharao Sidduri
Tetrahedron Letters, 2001
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The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma
Pieter Hiemstra
Allergy, 2006
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