Highly constrained bicyclic VLA-4 antagonists (original) (raw)

Discovery of N-{ N-[(3-cyanobenzene) sulfonyl]-4( R)-(3,3-difluoropiperidin-1-yl)-( l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-( l)-phenylalanine (MK-0617), a highly potent and orally active VLA4 antagonist

Shankar Venkatraman

Bioorganic & Medicinal Chemistry Letters, 2009

View PDFchevron_right

Influence of acid surrogates toward potency of VLA4 antagonist

Shankar Venkatraman

Bioorganic & Medicinal Chemistry Letters, 2005

View PDFchevron_right

N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Malcolm Maccoss

Bioorganic & Medicinal Chemistry Letters, 2002

View PDFchevron_right

2,6-Quinolinyl derivatives as potent VLA-4 antagonists

Abdoulaye Gassama

Bioorganic & Medicinal Chemistry Letters, 2007

View PDFchevron_right

Arylsulfonamide pyrimidines as VLA-4 antagonists

Elizabeth Messersmith

Bioorganic & Medicinal Chemistry Letters, 2013

View PDFchevron_right

Diamine containing VLA-4 antagonists

Andrew Morley

Bioorganic & Medicinal Chemistry, 2001

View PDFchevron_right

Anti-inflammatory activity of c(ILDV-NH(CH 2 ) 5 CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion

Christopher Reilly

British Journal of Pharmacology, 1999

View PDFchevron_right

The Design and Synthesis of Potent Cyclic Peptide VCAM-VLA-4 Antagonists Incorporating An Achiral Asp-Pro Mimetic

pramod joshi

Bioorganic & medicinal …, 2000

View PDFchevron_right

N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA4 antagonists

Quang Truong

Bioorganic & Medicinal Chemistry Letters, 2002

View PDFchevron_right

Discovery of N -{ N -[(3-Cyanophenyl)sulfonyl]-4( R )-cyclobutylamino-( l )-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-( l )-phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4

Malcolm Maccoss

Journal of Medicinal Chemistry, 2009

View PDFchevron_right

Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model

Mark Dreyer

Bioorganic & Medicinal Chemistry Letters, 2011

View PDFchevron_right

N-Cycloalkanoyl-l-Phenylalanine Derivatives as VCAM/VLA-4 Antagonists

Achyutharao Sidduri

Bioorganic & Medicinal Chemistry Letters, 2002

View PDFchevron_right

Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists

Thomas Reger

Bioorganic & Medicinal Chemistry Letters, 2010

View PDFchevron_right

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist

Zahid Hussain

Bioorganic & Medicinal Chemistry Letters, 2005

View PDFchevron_right

Amidines as amide bond replacements in VLA-4 antagonists

Stephen de Laszlo, Malcolm Maccoss

Bioorganic & Medicinal Chemistry Letters, 2004

View PDFchevron_right

Discovery of Very Late Antigen-4 (VLA-4, 4 1 Integrin) Allosteric Antagonists

Alexandre Chigaev

Journal of Biological Chemistry, 2011

View PDFchevron_right

Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin: From a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses

Daniele Bellocchi

ChemInform, 2004

View PDFchevron_right

Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

Dr. Tridib Chaira

Bioorganic & Medicinal Chemistry Letters, 2013

View PDFchevron_right

N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists

Clare Gutteridge

Bioorganic & Medicinal Chemistry Letters, 2003

View PDFchevron_right

Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas

Marla Weetall

Molecular diversity, 2000

View PDFchevron_right

3D QSAR (COMFA) of a series of potent and highly selective VLA4 antagonists

Herman van Vlijmen

Journal of Computer-aided Molecular Design, 2002

View PDFchevron_right

Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma

Hasan Arshad

The Journal of allergy and clinical immunology, 2005

View PDFchevron_right

Squaric acid derivatives as VLA-4 integrin antagonists

Richard Taylor

Bioorganic & Medicinal Chemistry Letters, 2002

View PDFchevron_right

Synthesis of constrained l-phenylalanine derivatives incorporating a benzazepinone or an azepinone ring as VCAM/VLA-4 antagonists

Achyutharao Sidduri

Tetrahedron Letters, 2001

View PDFchevron_right

The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma

Pieter Hiemstra

Allergy, 2006

View PDFchevron_right