Effects of Atorvastatin on LDL sub‐fractions and peroxidation in type 1 diabetic patients: a randomised double‐blind placebo‐controlled study (original) (raw)

BackgroundPatients with diabetes have an increased risk of both developing and dying from cardiovascular disease, and, currently, more aggressive lipid‐lowering targets are being recommended for these patients. Statins are widely and successfully used to correct dyslipidemia and prevent acute coronary episodes, but their effects on lipoprotein composition and peroxidation have not been fully investigated. We aimed to address this issue in type 1 diabetes mellitus.MethodsT1DM patients with atherogenic index (total/HDL‐cholesterol > 4) were randomised double‐blindly to group A (n = 12) that received Atorvastatin 40 mg/day and group P (n = 12) that received placebo. They were monitored for blood biochemistry, LDL sub‐fractions and lipid peroxidation at inclusion, after 6 and after 12 weeks.ResultsIn group A, the 40% decrease in serum total and LDL cholesterol and 20% decrease in triglycerides was accompanied by a decrease in serum α‐tocopherol from 46.4 ± 16.3 (mean ± SD) at inclusi...