Bone lesions simulating multiple myeloma: Unusual presentation of esophageal cancer (original) (raw)
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Carcinoma of the esophagus simulating multiple myeloma
Digestive Diseases and Sciences, 1966
In a patient with a small asymptomatic carcinoma of the esophagus and widespread metastases, multiple myeloma was simulated by the presence of osteolytic bone lesions, a narrow-band hyperglobulinemia, and marked bone marrow plasmocytosis. Administration of prednisone resulted in temporary improvement of systemic symptoms, suppression of the serum protein abnormality, and bone marrow plasmocytosis. Melphalan did not favorably affect the course
Indian Journal of Pathology and Oncology, 2023
Introduction: Bone marrow examination is an essential tool for diagnosis of many diseases including both hematological and non hematological tumors. Bone marrow is commonly involved by many metastatic solid tumors. Bone marrow aspirates, and biopsies have been found to be more useful than radiological investigations in early diagnosis of bone marrow metastasis. Case Report: Here we present a case of a 75 years old male patient presenting with acute sudden onset chest pain along with multiple lytic sclerotic foci in lumbar vertebrae, bilateral ribs, clavicle, scapula and sternum along with fractures in multiple ribs. CBC findings showed anemia with thrombocytopenia. Bone marrow examination revealed an infiltration of a metastatic tumor in bone marrow which was further confirmed to be of lower gastrointestinal tract in origin on IHC findings. Conclusion: A high suspicion for bone marrow metastasis should be considered in cases who present primarily with abnormalities in peripheral blood count and a vigilant search for metastatic cells on aspirate smears and imprint smears can help in early diagnosis of bone marrow metastasis by solid tumors. Keywords: Bone marrow metastasis, Bone marrow examination, Metastatic solid tumor.
A Rare Initial Presentation of Gastric Cancer with Multiple Osteolytic Lesions
Case Reports in Oncological Medicine, 2015
Gastric cancer is the 12th leading cause of cancer-related deaths in the United States and commonly metastasizes to the bones. However, the presentation of gastric cancer as bony metastases without preceding gastrointestinal symptoms is rare which has been infrequently reported in the literature. Moreover, leptomeningeal carcinomatosis is an unusual complication of gastric cancer accounting for less than 1 percent of these patients. We present a unique case of a middle aged male who presented to the emergency department with worsening backache which started one month priorly. The only abnormal laboratory test was an elevated alkaline phosphatase of 154 IU/L. The imaging of his spine showed osteolytic lesions which on biopsy revealed signet ring cells. A small 2 cm ulcerated mass was found on esophagogastroduodenoscopy at the gastric cardia which on biopsy revealed signet ring gastric carcinoma. The patient received chemotherapy with capecitabine and oxaliplatin as well as radiation and showed a good response initially. A few months later, he presented with persistent worsening headaches and on brain imaging was found to have leptomeningeal carcinomatosis. Ten months after the diagnosis of gastric carcinoma, he passed away.
An Unusual Presentation of Esophageal Cancer: A Case Report and Review of Literature
We present a case of a 49-year-old white female who complained of a chronic cough for 1 year. Computed tomography (CT) of the chest revealed abnormal thickening of the thoracic esophagus. Esophago-gastroduodenoscopy (EGD) revealed diffuse multiple masses in the esophagus, which appeared separate. Histopathology of the masses revealed adenocarcinoma.
Metastatic tumours in upper maxillary bone of esophageal adenocarcinoma. A case report
Medicina oral, patología oral y cirugía bucal
Metastases in the oral cavity are rare lesions which represent approximately 1% of all malignant neoplasms in the oral cavity. Oral metastases are located in the mandible 80-90% on average, the maxilla location being rarer. Metastases in mouth soft tissue are also rare, and within these it is on the gums where they more frequently occur. Primary tumours which metastasize to mouth are most commonly: lung, breast and kidney. Oral cavity metastases appear as a result of distant disease spreading and show wrong prognosis, with short survival. Here we present a clinical case of a patient diagnosed with esophagus adenocarcinoma which presented metastasis in upper-left maxillary bone.
Esophageal gastrointestinal stromal tumor with pulmonary and bone metastases
G astrointestinal stromal tumors (GISTs) are the most common nonepithelial tumors of the gastrointestinal tract (1). Their incidence by anatomic location varies in different studies: 51-70% in the stomach; 25-36% in the small intestine; 5-7% in the colon, rectum, and appendix; and 1-3% in the esophagus. Primary GIST can be found in the omentum, mesentery, or retroperitoneum, unrelated to the tubular gastrointestinal tract, but most in these sites are metastatic from gastric or intestinal primaries (2-7). The distribution of metastases is predictable, with the liver and peritoneum the most common sites (5, 8). The liver is the most common site of metastasis both at presentation and at disease relapse (5). Distant metastasis to other sites, especially the bones and lung, is relatively rare . We present radiologic findings in an unusual case of an esophageal GIST with pulmonary and bone lesions.