P1-409: Knockdown of plasminogen activator inhibitor 1 gene reduces cerebral amyloid-beta peptide burden in a mouse model of Alzheimer's disease (original) (raw)
2008, Alzheimer's & Dementia
AI-generated Abstract
This study investigates the role of plasminogen activator inhibitor 1 (PAI-1) in the accumulation of amyloid-beta (Aβ) in a mouse model of Alzheimer's disease (AD). Increased expression of PAI-1 was noted in both aging and AD mouse brains, and it was found to co-localize with Aβ. By creating APP/PS1/PAI-1 knockout mice, the study demonstrated significantly reduced levels of insoluble Aβ, providing evidence that PAI-1 expression contributes to Aβ accumulation and AD pathogenesis. These findings have important implications for therapeutic strategies targeting PAI-1 in AD.
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