A study of bile duct dynamics using computer-assisted99mTc-HIDA scintigraphy (original) (raw)
Related papers
2020
1 Center for Information Services and High Performance Computing, Technische Universität Dresden, 01062 Dresden, Saxony, Germany 2) Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Saxony, Germany 3) UCSF, Cardiovascular Research Institute, Department of Biochemistry and Biophysics, California, USA 4) Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, Technische Universität Dresden, 01187 Dresden, Saxony, Germany 5) Center for Systems Biology Dresden, 01307 Dresden, Saxony, Germany 6) Cluster of Excellence Physics of Life, Technische Universität Dresden, 01187 Dresden, Saxony, Germany
Observations on the distensibility of the common bile duct
Radiology, 1982
Observations on the Distensibility of the Common Bile Duct1 This series describes 9 patients in whom a rapid change in bile duct caliber was documented by ultrasonography, intravenous or direct cholangiography, or endoscopic retrograde cholangiopancreatography. Two major observations were made: (a) the capacity of the common duct to distend and collapse over a short period, and (b) discordant measurements of bile duct diameter on successive examinations with different modalities (i.e., ultrasonography followed by cholangiography). It is thought that these discrepant measurements can be explained by the ability of the common duct to distend rapidly in response to pathologic and physiologic fluctuations in biliary pressure. Index terms: Bile-duct radiography #{149} Bile ducts, dilatation #{149} Bile ducts, size #{149} Bile ducts, ultrasound studies #{149} (Liver, biliary intravenous cholangiography, 7[6].1223) #{149} (Liver, biliary percutaneous cholangiography, 7[6].1226) #{149} (Liver, biliary ultrasonography, 7[61.1298)
Experimental Investigation of the Flow of Bile in Patient Specific Cystic Duct Models
Journal of Biomechanical Engineering-transactions of The Asme, 2010
Three-dimensional scaled-up transparent models of three human cystic ducts were prepared on the basis of anatomical specimens. The measurement of pressure drop across the cystic duct models and visualization of the flow structures within these ducts were performed at conditions replicating the physiological state. The flow visualization study confirmed the laminar nature of the flow of bile inside the cystic duct and values of pressure drop coefficient ͑Cp͒ decreased as the Reynolds number (Re) increased. The three tested models showed comparable behavior for the curve of Reynolds number versus the pressure drop coefficient. The results show that the tested cystic ducts have both increased pressure drop and complicated flow structures when compared with straight conduits. High resistance in a cystic duct may indicate that the gallbladder has to exert large force in expelling bile to the cystic duct. For patients with diseased gallbladder, and even in healthy persons, gallbladder is known to stiffen with age and it may lose its compliance or flexibility. A high resistance cystic duct coupled with a stiffened gallbladder may result in prolonged stasis of bile in the gallbladder, which is assumed to encourage the formation of gallstones.
Neurogastroenterology & Motility, 2008
The relationship between the migrating motor complex (MMCj and the enterohepatic circulation was studied in 16 healthy young male volunteers using a combined technique of continuous pressure recording from the gastroduodenal region and scintigraphy with '"Se-homo-cholic-acid-taurine (','Se-HCAT). I n nine subjects (group 1 ) the radioactive marker was instilled in the duodenum immediately before a phase III complex of the MMC, and in seven subjects (group 2) in early phase II. I n group 1 , the gallbladder was visualized by scintigraphy at a median time of 45 (27-90)
Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease
World Journal of Gastroenterology, 2009
AIM: To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymptomatic gallstone disease. METHODS: Quantitative hepatobiliary scintigraphy was performed to detect the parameters of gallbladder motor function [gallbladder ejection fraction (GBEF), gallbladder visualization time (GBVT), gallbladder time to peak activity (GBT max), gallbladder half emptying time (GBT 1/2), and transit time of bile to duodenum (TTBD)] in 24 patients with asymptomatic cholelithiasis who were diagnosed incidentally during routine abdominal ultrasonographic examination and 20 healthy subjects with normal gallbladder. RESULTS: Even though there was no significant difference in the clinical and laboratory parameters between the patient and control groups, all parameters of gallbladder function except TTBD were found to differ significantly between the two groups. GBEF in the patient group was decreased (P = 0.000) and GBVT, GBT max , GBT 1/2 in the patient group were longer (P = 0.000, P = 0.015, P = 0.001, respectively). CONCLUSION: Our results showed that even if there were not any clinical and laboratory findings, gallbladder filling and emptying could be impaired in patients with gallstone disease.
Methods of measuring gallbladder motor functions—the need for standardization: scintigraphy
Digestive and Liver Disease, 2003
Emptying the gallbladder is part of the complex process of food digestion. The gallbladder interacts with other gastrointestinal organs and its movements are coordinated and modified by functions of the stomach, intestine and pancreas. Many factors can modify gallbladder motility, for example, sex and age of the subject, their body mass, the kinds of food ingested and stimulus used.
Computational analysis of the flow of bile in human cystic duct
Medical Engineering & Physics, 2012
Computational fluid dynamic (CFD) simulations of the three-dimensional flow structures in realistic cystic ducts have been performed to obtain quantitative readings of the flow parameters to compare with clinical measurements. Resin casts of real patients' cystic ducts lumen that possess representative anatomical features were scanned to obtain three-dimensional flow domains that were used in the numerical analysis. The convoluting nature of the studied cystic ducts resulted in strong secondary flow that contributed towards a dimensionless pressure drop that is four times higher than those of a straight circular tube of an equivalent length and average diameter. The numerical pressure drop results across the cystic duct compared very well with those obtained from clinical observations which indicate that CFD is an appropriate tool to investigate the flow and functions of the biliary system. From the hydrodynamic point of view, the cystic duct lumen seems to serve as a passive resistor that strives to provide a constant amount of resistance to control the flow of bile out of the gallbladder. This is mainly achieved by the coupling of the secondary flow effects and bile rheology to provide flow resistance.
Endoscopic Ex Vivo Evaluation of Bile Concentrations by Narrow Band Imaging: A Pilot Study
Gastroenterology Research and Practice, 2015
Background. Bile juice plays a major role in duodenogastroesophageal reflux (DGERD). Several devices to directly measure the bile concentration have been proposed. We aimed to ex-vivo evaluate the bile concentration by narrow band imaging (NBI).Method. From six surgical cholecystectomies, the content of the gallbladders was aspirated and the total biliary acid (TBA) concentration was evaluated. 2 mL was employed for serial twofold dilutions. Each dilution was scoped. Images on white light (WL) and NBI were captured and grouped accordingly to NBI-appearance and TBA-concentration.Results. Nondiluted bile had a TBA-concentration of 61965 ± 32989 μmol/L. Final dilution (1 : 4096) had 1.16 μmol/L. NBI and correspondent WL images were grouped into seven groups, and an NBI/Bile scale was created.Conclusion. The scale showed that not only NBI scale but also white light scale could be useful to predict the bile concentration. This initial study shows that NBI has a potential role in the dete...
SECT ION 1 Anatomy , pathophysiology , and epidemiology of the biliary system
2006
Intrahepatic bile ducts There are more than 2 km of bile ductules and ducts in the adult human liver. These structures are far from being inert channels, and are capable of signifi cantly modifying biliary fl ow and composition in response to hormonal secretion. Bile secretion starts at the level of the bile canaliculus, the smallest branch of the biliary tree [6]. They form a meshwork between hepatocytes with many anastomotic interconnec