Endothelium and oxidised lipoproteins (original) (raw)

The research explores the impact of oxidized lipoproteins, specifically oxidized LDL (OxLDL), on atherosclerosis and macrophage interactions. Evidence suggests that OxLDL plays a critical role in lesion formation, with antioxidants showing potential benefits in clinical settings. The study also examines the role of tissue inhibitors of metalloproteinases (TIMPs) in reducing atherosclerotic lesions through adenoviral-mediated overexpression in apoE-deficient mice, highlighting the inflammatory implications of metalloproteinases in the disease progression.