High density lipoprotein and kidney dysfunction among post kidney transplant patients (original) (raw)

Introduction: Dyslipidemia is commonly found in patients after kidney transplantation and it is associated with cardiovascular complications. Kidney transplant patients suffer high mortality due to cardiovascular diseases. Objective: Patients who have undergone kidney transplant, and present with chronic kidney disease (CKD) often have poor high-density lipoprotein (HDL) control. Hence, this study aims to establish a correlation between serum HDL levels in transplant recipients with kidney function. Design: A retrospective cross-sectional study, which examined 240 patients who underwent kidney transplant, and were followed up between 2006 and 2012. HDL values along estimated glomerular filtration rate (eGFR) were recorded, on a yearly basis, using Epi-Data entry software and then transferred to SPSS software for analysis. Results: A total of 106 patients are included out of our initial sample of 240, the rest 134 were excluded, for various causes. the age ranged from 14 to 76 years, with a mean of 42.7 years, and a median of 42 years. 62 of the included participants were males, 44 were female. Year of transplant varied from 1981 to 2013. 32 of the patients underwent live related renal transplant and 78 underwent commercial transplant. From the analysis we interpreted, with a continuity correction of p=1.000, that there was no statistically significant association between the two categorical variables (p>0.05). Conclusion: We found no statistically significant association between worsening HDL levels and renal function decline in our study population of patients who underwent renal transplant.