5,6-Dihydrobenzo[h]quinazoline (original) (raw)

2005, Acta Crystallographica Section E Structure Reports Online

AI-generated Abstract

5,6-Dihydrobenzo[h]quinazoline, a heterocyclic compound with the formula C12H10N2, has been synthesized using -tetralone and formamide through various palladium complexes as catalysts. The compound features a unique crystallographic arrangement, characterized by two molecules in the asymmetric unit, which adopt a perpendicular orientation, leading to a zigzag packing pattern.

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The crystal structure of 1,5-dibenzyl-1 H -pyrazolo[3,4- d ]pyrimidine-4(5 H )-thione

Acta Crystallographica Section E Crystallographic Communications, 2015

In the title compound, C19H16N4S, the pyrazolo[3,4-d]pyrimidine ring is close to being planar, with the greatest deviation from the mean plane being 0.023 (2) Å for the C atom bearing the thione S atom. The two phenyl rings are nearly perpendicular to the fused ring system [dihedral angles = 71.4 (2) and 78.1 (2)°], but are oriented in opposite directions; the dihedral angle between the phenyl rings is 32.22 (16)°. In the crystal, linear supramolecular chains along [101] are sustained by C—H...S interactions.

Crystal structure of 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one sulfadiazine dimethylformamide monosolvate, C30H29N7O4S

Zeitschrift für Kristallographie - New Crystal Structures, 2014

C 30 H 29 N 7 O 4 S, triclinic, P1 (no. 2), a =7.7793(3) Å, b =9.1053(4) Å, c =21.7108(9)Å,a=97.433(2)°, b =93.025(2)°, g =111.055(2)°, V =1414.9 Å 3 , Z =2, R gt (F) =0.0399, wR ref (F 2) =0.1084, T =200 K. Source of material The reagents were of analytical grade and wereused as obtained. To as olution of synthesized4-benzoyl-3-methyl-1-phenyl-2pyrazolin-5-one (2.0 mmol,0 .56g)i nm ethanol(10 mL)w as addedslowlytosulfadiazine(2.0mmol, 0.50 g) in methanol(10 mL)while stirring, and the mixture was refluxed for 3h.The pale yellow precipitate obtained was filtered, washed with methanol, dried at room temperature and stored over fused CaCl 2 .Yellow cubic single crystals of the titled ketoimine Schiff base good enough for x-ray diffraction were grown at room temperature from slow evaporation of dimethylformamide solution. Experimental details Carbon-bound Hatoms were placed in calculated positions and were included in the refinement in the riding model approximation, with U iso (H) sett o1 .2U eq (C). The Ha toms of the methyl groups were allowed to rotate with afixed angle around the CC bond to best fit the experimental electron density (HFIX 137 in the SHELX program suite [11]), with U iso (H) sett o1 .5U eq (C).

Design and synthesis of pyrazolo[3,4-d]pyrimidine core based dissymmetrical `Leonard linker' compounds: 1H NMR and crystallographic evidence for folded conformation due to arene interactions

J Mol Struct, 2006

Proton NMR analysis of two newly synthesized 'Leonard/trimethylene linker' dissymmetrical compounds 1-(4,6-dimethylsulfanyl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)-3-(5-methyl-6-methylsulfanyl-4-oxo-1,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)propane (8) and 1-(4-methoxy-6-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-(6-methoxy-5-methyl-4-oxo-1,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)propane (10) show intramolecularly stacked conformation in solution. X-Ray crystallography of dissymmetrical 'Leonard/trimethylene linker' compound (8) based on pyrazolo[3,4-d]pyrimidine core, for the first time, shows unusual U-motif formed due to intramolecular p-p stacking interactions, which is similar to earlier related symmetrical compounds 1 & 2. Supramolecular structures of new compound (8) show additional CH.O, CH.N, CH.S and S.S interactions.

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