The impact of extremely young age on the outcome of in vitro fertilization in good prognosis qatari women with infertility (original) (raw)
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Freeze-all policy for in vitro fertilization in women with normal response to ovarian stimulation
einstein (São Paulo), 2021
Objective: To answer the question if the freeze-all strategy and subsequent frozen embryo transfer is preferable to fresh embryo transfer for patients with normal response to ovarian stimulation (4 to 15 oocytes recovered) during in vitro fertilization treatments. Methods: A retrospective cohort from two human reproduction centers between 2013 and 2017. A total of 471 frozen embryo transfers from freeze-all cycles, and 3,208 fresh transfers were included. Results: After propensity score matching adjustment for age and number of eggs, 467 freeze-all cycles and 934 fresh cycles were analyzed, revealing no statistically significant difference between groups in relation to clinical pregnancy rate (32.5% in the Freeze-all Group and 32.3% in the Fresh Group, p=0.936). For women aged 40 years and older, we observed a statistically significant higher clinical pregnancy rate when freeze-all strategy was used (29.3% in the Freeze-all Group and 19.8% in the Fresh Group, p=0.04). Conclusion: Freeze-all strategy was not superior to fresh transfer for all patients with normal response to ovarian stimulation. However, women aged 40 years and older could benefit from this strategy. This deserves further investigation in future research, preferable in a prospective randomized study.
Fertility and sterility, 2018
To assess in vitro fertilization (IVF) and pregnancy outcomes in patients having their first frozen embryo transfer (FET) after a freeze-all cycle versus similar patients having their first fresh embryo transfer (ET). Retrospective cohort study. None. Registry data on 82,935 patient cycles from the Society for Assisted Reproductive Technology (SART). All first fresh autologous IVF cycles were analyzed and compared to first FET cycles after a freeze-all first IVF stimulation. The cycles were subdivided into cohorts based upon the number of oocytes retrieved (OR): 1-5 (low), 6-14 (intermediate), and 15+ (high responders). Univariate analyses were performed on cycle characteristics, and multivariable regression analyses were performed on outcome data. Clinical pregnancy rate (CPR) and live-birth rate (LBR). Of the 82,935 cycles analyzed, 69,102 patients had their first fresh transfer, and 13,833 had a first FET. High responders were found to have a higher CPR and LBR in the FET cycles ...
Reproductive BioMedicine Online, 2011
A Weissman). Dr Ariel Weissman graduated from the Hadassah-Hebrew University Medical School in Jerusalem in 1988. In 1994 he completed his residency in obstetrics and gynaecology at the Kaplan Medical Centre, Rehovot, where he spent another 2 years working as a senior physician in the IVF unit. He then pursued a 2-year research and clinical fellowship with Bob Casper at the Division of Reproductive Sciences, University of Toronto, Canada. His main focus of research was transplantation of human ovarian tissue in immunodeficient mice. In 1998, he joined the IVF unit at the Wolfson Medical Centre, where he currently holds a position of senior lecturer.
Journal of Assisted Reproduction and Genetics, 2010
Introduction The purpose of this retrospective analysis is to compare the efficiency of hCG-induced natural and Clomiphene citrate (CC) cycles in normovulatory patients undergoing frozen embryo transfer (FET). Materials and methods It was retrospectively conducted in the Dutchspeaking Free University of Brussels and covered the period from April 2003 to August 2006. In particular, 428 day-three FET cycles belonging to the two comparative groups were recruited. Of these FET cycles, 261 were hCG-induced natural and 167 clomiphene citrate-induced cycles.
Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
Frontiers in Medicine, 2021
Objective: The aim of this study is to investigate, in ovulatory patients, whether there is a difference in reproductive outcomes following frozen-thawed embryo transfer (FET) in natural cycles (NC) compared to modified natural cycles (mNC).Methods: This retrospective cohort study, performed at the public tertiary fertility clinic, involved all infertile patients undergoing endometrial preparation prior to FET in NC and mNC from January, 2017 to November, 2020. One thousand hundred and sixty-two patients were divided into two groups: mNC group (n = 248) had FET in a NC after ovulation triggering with human chorionic gonadotropin (hCG); NC group (n = 914) had FET in a NC after spontaneous ovulation were observed. The primary outcome was live birth rate. All pregnancy outcomes were analyzed by propensity score matching (PSM) and multivariable logistic regression analyses.Results: The NC group showed a higher live birth rate [344/914 (37.6%) vs. 68/248 (27.4%), P = 0.003; 87/240 (36.3%...
Vol 16, No 4, October-December , 2022
Background: Gonadotropin-releasing hormone antagonis t (GnRH-ant), widely adopted protocol, is more in line with the physiological processes, and induces a shorter and more cos t-effective ovarian s timulation. In order to assess the success rate of embryo transferring (ET) in the antagonis t in vitro fertilization (IVF) cycles, we compared the fresh ET with the frozen ET outcomes. Materials and Methods: In this retrospective cohort s tudy, one hundred five cases of ET of the infertility clinic of the Besat hospital (Kurdis tan, Iran) between March 2014 to March 2020 that were treated with antagonis t cycle (both fresh and frozen) were analyzed. The difference between the two groups in baseline data and reproductive outcomes were evaluated using Independent sample t tes t, Mann-Whitney U tes t, Chi-squared tes t, and Fisher's exact tes t in SPSS software (version 22). Results: Out of 105 cases, 48 and 57 were in the fresh and frozen ET groups, respectively. The participants age was 35.75 ± 4.9 Y. In the fresh ET group, and 33.98 ± 5.1 Y in the frozen ET group. The percentage of chemical pregnancy was 12 (25%) in the fresh ET group and 15 (26.3%) in the frozen ET group (P=0.8); Clinical pregnancy rate was 11 (22.9%) in the fresh ET group and 11 (19.3%) in the frozen ET group (P=0.6); the rate of abortion in the fresh ET group was 3 (6.3%, P=0.2), and in the frozen ET group was 8 (14%, P=0.2); and the live birth rate was 9 (18.8%) in the fresh ET group, in comparison with 7 (12.3%) in the frozen ET group (P=0.3). Conclusion: Not s tatis tically significant, the percentage of chemical pregnancy and abortion were higher in the frozen ET group. The percentage of clinical pregnancy and live birth were higher in the fresh ET group.
Journal of Assisted Reproduction and Genetics, 1996
Objective: Our objective was to assess paranzeters associated with a succes.~Jhl outcome o.f intrauterine insemination (IUI) using crvopreserved donor sperm. Design: We analyzed 750 consecutive donor IUI cycles undertaken hv 363 women in an assisted conception clinic. The main olttcome measure was clinical pregnancy. Results: 1U1 was pel¢ormed i/~ 94. 7% of the 750 IUI treatment cycles contmenced and 180 clinical pregnancies occurred. The clinical pregnancy rate per cTcle was 26.4%. The rate was sign(ficantO, related to the patient's age (30.5% fi~r age <-35 years and 18.1% for age >35 years; P < 0.0¢161 and whether there was one or more than one preovulatory follieles [20.9, 34,4, and 31.5% for one, two, and three or four follicles with a nlean diameter of 14 or nlore m m at the time of human chorionic gonadotropin (hCG) administration: P = 0.006]. Two to four preovulatory follicles were present in 12.6% of the natural o'cles, 43.6% of clomiphene citrate or tamoxifen, and 59.9% of gonadotropin stinudated cycles. The difference in the number of preovalatoo, follicles between stimulated and unstimutated cvcles was high(v significant (P < 0.0001). Pregnancy rates were 29.9°/,, in gonadotropin-stimulated cycles, 23.6% in clomiphene citrate-or tamoxifen-stimulated cycles, and 20.1% m unstimlduted cvcles. The difference in pregnancy rates between gonadotro-~The London Women's Clinic,
Fertility and Sterility, 2006
Objective: To document outcomes of oocyte cryopreservation performed as a routine procedure in an IVF program. Design: Describing the rate of oocyte survival, embryo transfer (ET), implantation, and live births of IVFintracytoplasmic sperm injection performed on thawed oocytes. Setting: Reproductive medicine center in Italy. Patient(s): Women (n ϭ 696) who failed to conceive after IVF-intracytoplasmic sperm injection with fresh oocytes. Intervention(s): Surplus oocytes obtained during a failed cycle with fresh oocytes were frozen and then were thawed, micromanipulated, and transferred in a later cycle. Main Outcome Measure(s): Rates of oocyte survival, ETs, implantation, and live births were calculated in the entire cohort and in patients aged Յ38 and Ͼ38 years. Result(s): There were 29 pregnancies, for a total implantation rate of 6.3% (95% CI: 4.3, 9.0) per 456 ET cycles. The clinical-pregnancy rate was 19 (4.2%; 95% CI: 2.6, 6.4) of 456 ET cycles, with a take-home-baby rate of 7 (1.5%; 95% CI: 0.7, 3.0) of 456 ET cycles. Conclusion(s): Cryopreservation performed as a routine procedure for so-called salvaging of surplus oocytes is associated with poor implantation rates and with a probability of 1 live birth in 65 ET cycles. (Fertil Steril 2006; 86:1423-7.