Seroevidence of Chlamydia trachomatis antibody in infertile women in University of Benin Teaching Hospital (Ubth) Benin City, Nigeria (original) (raw)
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Effects of Chlamydia trachomatis Infection on Fertility; A Case-Control Study
Journal of reproduction & infertility, 2013
Nowadays, Chlamydia trachomatis is known as a causative agent of infertility. Because of, asymptomatic nature of infection, many may suffer from its lasting complications such as infertility. This study was performed in Tehran during April 2007 to April 2008 to compare the prevalence of Chlamydia trachomatis infection in fertile and infertile women using ELISA and PCR methods. Overall, 234 infertile and 223 pregnant women, as the fertile group, participated in this hospital-based case-control study. After completing an informed consent form and the questionnaire, first catch urine and blood sample were obtained for PCR and ELISA (IgG, IgM) tests, respectively. Logistic regression analysis was used to control possible confounding factors, and determine adjusted odds ratio of infertility due to the infection. PCR results revealed that 29 (12.4%) of the infertile and 19 (8.5%) of the fertile women were positive for C. trachomatis infection (p = 0.440). IgG was positive in 21 (9.0%) of ...
Pathophysiological Changes in Infertile Women Infected with Chlamydia Trachomatis
2015
Chlamydia trachomatisis obligatory intracellular gram-negative bacteria that mainly infect the female urethra, cervix and fallopian tubes which is the popular bacterial of sexually transmitted infection (STI) globally. The objective of this study was to determine the infertility of infected women with C. trachomatis. This study was conducted at Obstetrics and Gynecology department and fertility center at ALSADER teaching hospital. Two hundred female were enrolled in current study were divided one hundred of those female was considered the study group with unexplained primary infertility and other100 females were considered as control group. Chlamydia trachomatis was detected by ELISA and PCR. Ultrasound examination, Hysterosalpingogram (HSG) for infertile women and Hormone tests included LH, FSH, E2, Prolactin and Testosterone were achieved all for all women participated in this study during the period from November 2013 to January 2015. The results of this study showed the mean age...
Chlamydia trachomatis infection in women with secondary infertility
Fertility and Sterility, 2009
To assess the role of Chlamydia in secondary infertility in a prospective study. Forty women with secondary infertility and 30 healthy term pregnant women of similar age composition were studied for past and present Chlamydia trachomatis infection. Women attending the outpatient Department of Obstetrics and Gynaecology with complaint of secondary infertility were enrolled as patients in the study. Forty women with secondary infertility formed the study group, and 30 healthy women served as the controls. Chlamydia IgG was detected by ELISA; titers of 1:320 or more were considered positive. Endocervical swabs were collected for culture on cycloheximide-treated McCoy cell lines, and ELISA was used to detect Chlamydia antigen. Hysterosalpingography was performed to assess tubal patency. A difference was expected between the prevalence of C. trachomatis infection in the infertile study subjects and fertile control group. Immunoglobulin G antibodies were present in 22 (55%) women with secondary infertility, whereas positivity was seen among 2 (5.5%) controls. Tubal occlusion occurred in 16 (63.6%) cases positive for chlamydial antibody. Sensitivity of chlamydial IgG antibody as a diagnostic marker for infertility was 72.7%, and specificity was 44.4%. The majority of Chlamydia IgG antibody-positive cases, 17 (77.2%), were symptomatic. Unfavorable obstetric history was found in 16 (72.7%) cases. Active infection was found in 12 (30%) cases with one (3.3%) case of current infection occurring in the controls. Prevalence of past chlamydial infection is strongly statistically significant in women with secondary infertility. Current infection was also found statistically significantly in these women. Immunoglobulin G antibody detection is an effective and noninvasive tool for detection of Chlamydia and a more viable option than HSG in a developing country such as India. Screening of women with secondary infertility for C. trachomatis is strongly recommended to allow early therapeutic interventions.
Chlamydia trachomatis urogenital infection in women with infertility
Advances in Medical Sciences, 2009
Purpose: The study objective was to evaluate the prevalence of urogenital Chlamydia trachomatis (C.tr.) infection in women with diagnosed infertility. Material and methods: The study involved patients from the Department of Gynecological Endocrinology and from the Center for Reproductive Medicine "Kriobank" in Bialystok. Female patients (n=71), aged 23-41, were divided into two groups according to the main diagnosis: A-tubal infertility (23) and B-infertility of another origin (48). For direct testing, PCR method was used to detect C.tr. infection in cervical samples (Roche, Molecular Systems, N.J., USA). Specific IgA and IgG anti-chlamydial antibodies in the serum were determined by immunoenzymatic assay (medac, Hamburg, Germany). Diagnostic procedures were performed at the Centre for STD Research and Diagnostics in Bialystok. Results: In group A, C.tr. infection was detected in: 8.7% patients, in group B-8.3%. Specific anti-C.tr. antibodies IgA were detected in: 13.0% in group A and 6.3% in group B, IgG respectively in 39.1% and in 10.4%. Conclusions: 1. C.tr. infection is very important etiological factor of female infertility. 2. The detection of specific antichlamydial antibodies is a valuable, noninvasive diagnostic procedure. 3. Infertile women should be routinely tested for C.tr. infection.
Current Chlamydia trachomatis Infection, A Major Cause of Infertility
Journal of reproduction & infertility, 2012
In India, the impact of current Chlamydia trachomatis (C. trachomatis) in reproductive health remains a neglected area of investigation. The present study evaluates if current Chlamydia infection is associated with any clinical complication that needs the attention of clinical investigators. In this cross-sectional study, we enrolled 896 women attending the Gynecology Out Patient for the detection of C. trachomatis infection. Polymerase chain reaction was used to diagnose current C. trachomatis infection and ELISA for past infections. Bacterial vaginosis, Candida and Trichomonas were screened. The results of symptomatic and asymptomatic groups were compared. The data was analyzed using Epi Info version 6 and "Z" test. A probability value of p≤0.05 was considered as significant.. Statistical analysis revealed significant association between current C. trachomatis infection with infertility when comparing infected fertile (18.6% vs. 9.4%, odds ratio: 2.19, p<0.0005) and u...
Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women
Clinical microbiology reviews, 2015
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen worldwide. Infection can result in serious reproductive pathologies, including pelvic inflammatory disease, ectopic pregnancy, and infertility, in women. However, the processes that result in these reproductive pathologies have not been well defined. Here we review the evidence for the human disease burden of these chlamydial reproductive pathologies. We then review human-based evidence that links Chlamydia with reproductive pathologies in women. We present data supporting the idea that host, immunological, epidemiological, and pathogen factors may all contribute to the development of infertility. Specifically, we review the existing evidence that host and pathogen genotypes, host hormone status, age of sexual debut, sexual behavior, coinfections, and repeat infections are all likely to be contributory factors in development of infertility. Pathogen factors such as infectious burden, treatment failure, ...
Journal of reproduction & infertility, 2013
Chlamydia trachomatis is the most reported bacterial sexually transmitted disease, especially among young women worldwide. The aim of this study was comparison the prevalence of Chlamydia trachomatis infection in woman with tubal infertility by means of PCR and cell culture techniques. Fifty-one women with confirmed TFI were enrolled in this study in (avicenna infertility Clinic) between January 2010 and January 2011. Cervical swab and cytobrush specimens were collected from each patient by gynecologists and sent to laboratory in transport media. Detection of Chlamydia trachomatis in samples was performed using PCR and bacteria culture in MacCoy cell line. The data were analyzed by Fisher's exact test and independent t-test. Statistical significance was established at a p-value <0.05. A significant relation was observed between increased the age of first intercourse and chlamydial infection. Six (11.7%) samples had positive PCR result, whereas cell culture results were positi...
Chlamydia Trachomatis Infection Amonginfertile Women At The University College Hospital, Ibadan
Medical Journal of Zambia
Background: Chlamydia trachomatis infection is reported as the commonest cause of tubal and pelvic infection and by proxy, the commonest cause of tubal damage and female infertility. Serotypes D-K are known to cause sexually transmitted genital tract and neonatal infection. Testing for the presence of Chlamydia trachomatis has been revolutionized by the development of monoclonal antibodies. This study sought to determine the prevalence of Chlamydia trachomatis infection among infertile women at the University College Hospital Ibadan and to determine the diagnostic value of Chlamydia antibody testing. Methodology: A cross-sectional study conducted among two hundred and seventy-three women with infertility attending the gynaecology clinic of the University College Hospital Ibadan. Hysterosalpingography (HSG) was performed on all patients as part of their routine evaluation for infertility. Venous blood was obtained to detect Chlamydia Ig G antibodies using the diagnostic bio-probe (DI...
Open Access Macedonian Journal of Medical Sciences, 2019
AIM: To determine the relationship between Chlamydia Trachomatis infections with patency tubal and non-patency tubal occurrence in infertile women. METHODS: This research was an observational analytic research with a cross-sectional study. This research was conducted at Haji Adam Malik General Hospital Medan, Pramita Laboratory Medan and Medical Faculty of Medicine Universitas Sumatera Utara. Laboratory on October 2017 until the number of samples was fulfilled. The samples were women who were referred to Pramita Laboratory Medan for hysterosalpingography procedure in accordance which corresponded to the inclusion criteria by using consecutive sampling technique. RESULTS: From this research, it was found that the most infertile women were aged 31-35 years, with the most infertility type was primary infertility (83,8%) with the longest infertility duration was ≥ 3 years (44%). From all samples who were infertile, 26% among them were positive to chlamydia infection. Eight from twelve p...