Inhibitors of Plasmepsin II—potential antimalarial agents (original) (raw)

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Alan Cowman

Cell Host & Microbe, 2020

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Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target

Angel Rafael Ramirez Ramirez

Biotechnology and Applied Biochemistry, 2009

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Active site specificity of plasmepsin II

B. Dunn, John Dame

Protein Science, 1999

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Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

Roberta Spaccapelo

The American Journal of Pathology, 2010

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Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Ilaria Russo

PLOS ONE, 2015

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Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design

Christopher Thomas Flood

Bioorganic & Medicinal Chemistry Letters, 2011

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Plasmodium:Drug Discovery and Development—An Industrial Perspective

Dr. Robert Ridley

Experimental Parasitology, 1997

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Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Alan Cowman

Plos Biology, 2014

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Antimalarial activity and pharmacokinetic properties of new chemical entities

Ntokozo Shirley Dambuza

2013

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Crystallography and Biopharmaceutics of Some Antimalarials

Augustine Okhamafe

British Journal of Pharmaceutical Research, 2015

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Expanding the Antimalarial Drug Arsenal—Now, But How?

Brian Grimberg

Pharmaceuticals, 2011

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A candidate antibody drug for prevention of malaria

Daniel Emerling

Nature Medicine, 2024

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Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man

John Dame

Molecular and Biochemical Parasitology, 2003

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A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress

Paco Pino

Science

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Contribution of Mass Spectrometry to the Study of Antimalarial Agents

Ana Sitoe

Tandem Mass Spectrometry - Molecular Characterization, 2013

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High Antiplasmodial Activity of Novel Plasmepsins I and II Inhibitors

Donatella Taramelli, Anna Sparatore

Journal of Medicinal Chemistry, 2006

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Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates

Prince Nyarko

International Journal for Parasitology: Drugs and Drug Resistance, 2017

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In Vivo Antiplasmodial Potentials of the Combinations of Four Nigerian Antimalarial Plants

Paul Nwafor

Molecules, 2014

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Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor

Ben Dunn

Acta Crystallographica Section D Biological Crystallography, 2006

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Inter-relação do ritmo e da ação de drogas antimaláricas na infecção da malária de roedores

Piero Bagnaresi

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New process for the manufacture of α-1 antitrypsin

joan dalton

Journal of Chromatography A, 2007

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In Vitro Inhibition of Plasmodium Falciparum by Substances Isolated From Amazonian Antimalarial Plants

Sergio Nunomura

Memórias do Instituto …, 2007

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Apical Surface Expression of Aspartic Protease Plasmepsin 4, a Potential Transmission-blocking Target of the Plasmodium Ookinete

John Dame

Journal of Biological Chemistry, 2010

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In vitro anti-plasmodial activity of some traditionally used medicinal plants against Plasmodium falciparum

Natarajan Gopalan

Parasitology …, 2012

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Development of vaccines against malaria

Klavs Berzins

International Journal of Immunopharmacology, 1994

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Antiplasmodial Quinones from Pentas longiflora

Abiy Yenesew

2012

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Clearance of Drug-Resistant Parasites as a Model for Protective Immunity in Plasmodium Falciparum Malaria

Yacouba Cissoko

The American Journal of Tropical Medicine and Hygiene, 2003

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Recent advances in identification of potential drug targets and development of novel drugs in protozoal diseases. Part IV. Apicomplexans and Plasmodium spp

Sherif Abaza

Parasitologists United Journal, 2022

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Role of plant secondary metabolites as potential antimalarial drugs

Dr. Ujjawal Sharma

International Journal of Mosquito Research

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Preliminary in silico study of a novel paratransgenic weapon against malaria

Michelle Fidelia

Deleted Journal, 2024

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Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion

Naresh Singh

PLoS Pathogens, 2006

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Design of New Plasmepsin Inhibitors: A Virtual High Throughput Screening Approach on the EGEE Grid

Marc Jacobs

Journal of Chemical Information and Modeling, 2007

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Malarial Subjects

Rohan Deb Roy

2017

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New imidazolidinedione derivatives as antimalarial agents

Victor Melendez

Bioorganic & Medicinal Chemistry, 2011

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Host-directed therapy, an untapped opportunity for antimalarial intervention

Christian Doerig

Cell Reports Medicine, 2021

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