Phenylpropanoids from Myristica fragrans Houtt (original) (raw)

Journal of The Korean Society for Applied Biological Chemistry, 2004

Abstract

Myristica fragrans Houtt were extracted in 80% aq. MeOH and solvent fractionated sing , EtOAc, n-BuOH and water, successively. The n-BuOH fraction gave three phenylpropanoids through application of silica gel column chromatographies. The chemical structures of the phenylpropanoids were determined by the interpretation of several spectral data, including NMR and MS as meso-dihydroguaiaretic acid (1), nectandrin B (2) and syringin methyl ether (3). Compound 1, which was first isolated from this plant by authors, showed inhibitory activities with on ACAT(acyl-CoA:Cholesterol Acyltransferase), chitin synthase III and HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase), respectively. Compound 3 showed inhibitory activities with on ACAT and chitin synthase III.

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