TRAIL receptor 1 (DR4) is frequently methylated in ovarian cancer: Relevance for TRAIL sensitivity and ovarian cancer tumorigenesis (original) (raw)

TRAIL receptor 1 (DR4) is frequently methylated in ovarian cancer: Relevance for TRAIL sensitivity and ovarian cancer tumorigenesis

AACR Meeting …, 2005

Abstract

Introduction. Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a type II transmembrane protein of the TNF family. It can be cleaved from the membrane into its soluble form and bind the apoptosis activating receptors DR4 and DR5. In ovarian cancer, elevated TRAIL ...

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