Synthesis and characterization of antibiotic-metal complexes [FeCl3(L1)2H2O and Ni(NO3)2(L2)2H2O] and enhanced antibacterial activity (original) (raw)
Related papers
2014
Complexes of Co(II), Ni(II) and Fe(III) with ampicillin and amoxicillin as ligands have been synthesized in aqueous solution and characterized by physical, IR and electronic spectra. The elemental data obtained agreed with the general formula [M(A)(C)].3H2O, where A= amoxicillin, C= ampicillin and M= metal ion. The IR spectra shows that the ligands coordinated to the metal ions through v(C=O), v(COO) and v(N-H) respectively due to their structural similarities. Electronic spectral data further revealed the probable geometry of Co(II) and Fe(III) complexes to be octahedral, while that of Zn(II) complex is tetrahedral. All the complexes and the ligands were screened for their biological activity on some selected bacterial species which includes:- Staphylococcus aurous, Streptococcus pyogene, Bacillus subtilis, Escherichia coli, Salmonella shigela, Klebsiella pneumoniae and Pseudomonas aeuroginosa. The results of biological activity indicated that the Co(II) and Ni(II) complexes have i...
Macrocyclic ligands are polydentate ligands containing donor atoms either incorporated or attached to cyclic backbone and showed significance in various biological studies. Tetraaza macrocyclic complexes of transition metals, Ni(II), Cu(II), Fe(III), and Mn(II) were synthesized in methanolic media using template method. These complexes were non-hygroscopic and consist of crystalline solids. Structural identification of these complexes was done using analytical techniques UV-Vis and IR Spectroscopy. The antibacterial activities of macrocyclic complexes (1-6) were screened against both Gram-negative bacteria (Escherichia coli and Vibrio cholerae) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus). In the present study we have reported that these synthesized complexes showed slight antibacterial activity except macrocyclic complex (6) which showed moderate antibacterial activity.
Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects
International Journal of Biomaterials
The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has reduced drastically against many microbes such as microfungi and bacteria (Gram-positive and Gram-negative). A ray of hope, however, was witnessed in early 1940s with the development of new drug discovery and use of metal complexes as antibiotics. Many new metal-based drugs were developed from the metal complexes which are potentially active against a number of ailments such as cancer, malaria, and neurodegenerative diseases. Therefore, this review is an attempt to describe the present scenario and future development of metal complexes as antibiotics against wide array of microbes.
Metal Complexes as a Promising Source for New Antibiotics
There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Antibiotic compounds are notorious for not having very “drug-like” chemical structures. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strai...
Ni(II), Zn(II) TERNARY METAL COMPLEXES: SYNTHESIS, CHARACTERISATION AND ANTI BACTERIAL ACTIVITY
Journal of emerging technologies and innovative research, 2019
Two novel and air stable ternary Ni(II) and Zn(II) metal complexes namely [Ni(L1) (L2)H2O] (1) [Zn(L1) (L2) H2O] (2) where L1=2,6-bis (benzimidazole-2 yl) pyridine (BBP) and L2= Oxalate ion(AA) were synthesized and characterized by elemental analysis, molar conductance , magnetic susceptibility measurements, TGA, DTA studies, HRMS, IR, electronic spectra , SEM-EDX , powder XRD studies. Based on elemental analysis, electronic spectra, conductance and magnetic moment measurements, six coordinated geometries were assigned to all the four metal complexes. Both the complexes are non electrolytic in nature. Powder XRD studies proved that the complexes were in nano crystalline phase. Antibacterial activity of metal complexes was checked against 3 gram positive (MRSA, B.cereus .B.subtilis) and 3 gram negative bacterial pathogens ( P.aeruginosa ,E.coli, P.vulgaris). Both the metal complexes inhibited the growth of bacterial strains and exhibited highest zone of inhibition against P.aeruginos...
Studies of Transition Metal Complexes and Their Antibacterial Activities
Tetraaza Macrocyclic complexes of transition metals of Ni (II), Cu(II), Cr(III), Fe(III), Mn(II) were synthesized in methanolic media by template method. The complexes were characterized by elemental analysis, UV-Vis, Infrared spectroscopy. In vitro antibacterial activity of macrocyclic complexes against five bacteria i.e. Streptococcus mutans, Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae were tested to assess their inhibiting the activities and compared with standard with ampicilline.
We synthesized iron(III), cobalt(II), copper(II) and zinc(II) complexes [Fe III (HBPClNOL)Cl 2 ]·H 2 O (1), [Co II (H 2 BPClNOL)Cl 2 ] (2), [Cu II (H 2 BPClNOL)Cl]Cl·H 2 O (3), and [Zn II (HBPClNOL)Cl] (4), where H 2 BPClNOL is the ligand (N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chloro)(2-hydroxy)]propylamine). The complexes obtained were characterized by elemental analysis, IR and UV–visible spectroscopies, electrospray ionization mass spectrometry (ESI-MS), tandem mass spectrometry (MS/MS), and cyclic voltammetry. X-ray diffraction studies were performed for complexes (3) and (4) revealing the presence of mononuclear and dinuclear structures in solid state for (3). However, the zinc complex is mononuclear in solid state. Biological studies of complexes (1)–(4) were carried out in vitro for antimicrobial activity against nine Gram-positive bacteria (Staphylococcus aureus strains RN 6390B, COL, ATCC 25923, Smith Diffuse, Wood 46, enterotoxigenic S. aureus FRI-100 (SEA+), FRI S-6 (SEB+) and SEC FRI-361) and animal strain S. aureus LSA 88 (SEC/SED/ TSST-1+). The following sequence of inhibition promoted by the complexes was observed: (4) N (2) N (3) N (1), showing the effect of the metal on the biological activity. To directly observe the morphological changes of the internal structure of bacterial cells after the treatment, transmission electron microscopy (TEM) was employed. For the most active complex [Zn II (HBPClNOL)Cl] (4), granulation deposits around the genetic material and internal material leaking were clearly detected.
Asian Journal of Chemistry, 2019
This paper describes the synthesis, spectral studies and antimicrobial properties of the complexes with the formula [M(C30H24N4O2)Cl2], where M = Fe(II), Co(II), Ni(II), Zn(II) and Cu(II). These complexes were prepared by yield effective template condensation of hexamethylenediamine and 2,2-dihydroxyindane-1,3-dione(ninhydrin). The synthesized complexes were characterized by elemental analysis, infrared spectra, thermogravimetric analysis, Mass spectrum, 13C NMR, molar conductance, electronic spectra, magnetic measurements. TGA and X-ray diffraction studies were used to ascertain the crystal structure and thermal stability of the complexes. The antimicrobial properties of complexes against two Gram-positive bacteria and two Gram-negative bacteria were evaluated by Agar well diffusion technique. Streptomycin and chloramphenicol were taken as standard antibiotics. The results shows that some of the complexes have potential to act as antibacterial agents.
Journal of Trace Elements in Medicine and Biology, 2013
The synthesis and characterization by elemental analysis, emission atomic spectroscopy, TG measurements, magnetic measurements, FTIR, 1 H NMR, UV-visible spectra and conductivity of a series of iron (II) and nickel (II) complexes with two heterocyclic ligands (L 1 (SMX): sulfamethoxazole and L 2 (MIZ): metronidazole) used in pharmaceutical field and with a new ligand derived benzoxazole (L 3 (MPBO): 2-(5methylpyridine-2-yl)benzoxazole), were reported. The formulae obtained for the complexes are: [M(L 1) 2 Cl 2 ]•nH 2 O, [M(L 2) 2 Cl 2 (H 2 O) 2 ]•H 2 O and [M(L 3) 2 (OH) 2 ]•nH 2 O. Stability constants of these complexes have been determined by potentiometric methods in water-ethanol (90:10, v/v) mixture at a 0.2 mol L −1 ionic strength (NaCl) and at 25.0 ± 0.1 • C. Sirko program was used to determine the protonation constants as well as the binding constants of three species [ML 2 H 2 ] 2+ , [ML 2 ] and [ML] 2+. The antimicrobial activity of the ligands and complexes was evaluated in vitro against different human bacteria and fungi using agar diffusion method. Iron sulfamethoxazole complex showed a remarkable inhibition of bacteria growth especially on Staphylococcus aureus and P. aeruginosa. The iron metronidazole complex is active against yeasts especially on Candida tropicalis strain. Nickel complexes presented different antibacterial and antifungal behavior's against bacteria and fungal. The acute toxicity study revealed that the iron complexes are not toxic at 2000 mg/kg dose orally administrated. LD 50 for nickel complexes was determined using graphical method. No significant differences in the body weights between the control and the treated groups of both rat sexes in subacute toxicity study using for iron complexes. Hematological and clinical blood chemistry analysis revealed no toxicity effects of the iron complexes. Pathologically, neither gross abnormalities nor histopathological changes were observed for these complexes.
Some macrocyclic complex compounds of Ni (II), Cu (II) and Fe (II) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C 3 H 8 N 4 O 2 ) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties. The IR spectrum study of the complex compounds suggests that ligand coordinates to metal ions through the nitrogen atoms from the tetraoxotetrahydrazin moity. Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria.