PO-1022: Outcome of cervix cancer patients treated with CT based plans - data from a limited resource setting (original) (raw)

2015, Radiotherapy and Oncology

, 157 pts (median age 64 years-range 39-84) were enrolled. All pts underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy with or without pelvic lymphadenectomy; patological stage (FIGO 2008) was I in 150 pts and II in 7 pts. Tumour grading was G1 in 49 pts, G2 in 98 and G3 in 10. All pts underwent high-dose-rate vaginal brachytherapy (total dose 21 Gy in three week-fractions), delivered with vaginal cylinder, with the reference isodose covering the proximal ½ of the vagina. The dose was specified at 5 mm distance from the cylinder surface. The Kaplan-Meier method estimated the probability of locoregional relapse free survival (LRFS), distant metastases-free survival (DMFS) and cancer-specific survival (CSS). Univariate analysis investigated the effect of age, grading, number of excised nodes and pathological stage on loco-regional relapse (LRR), metastases, and tumour-related death. Risk factors in univariate analysis were included in proportional hazard multivariate models. Vaginal toxicity was evaluated with the RTOG/EORTC scale and was correlated with the cylinder diameter (2.5, 3 or 3.5 cm). Results: LRFS occurred in 9/157 (5.8%) pts. Three pts (1.9%) developed liver metastases. At median follow-up of 83 months 144 pts (91.8%) are alive and disease free, 2 pts (1.2%) are alive with disease, 7 pts (4.5%) died from disease and 4 pts (2.5%) died from other causes. The 3-year probability of LRFS, DMFS and CSS was 94.

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