Local effects induced by coral snake venoms: evidence of myonecrosis after experimental inoculations of venoms from five species (original) (raw)

J . M . Ovr»SnnEZ, B . LOMONiZ, E . PORTILIA, L. Ceanes and E. Roles . Local effaxs induced by coral snake venons : evidence of myonaxosis after experimental inoculations of venons from five species . Taxirnn 21, 777-783, 1983 . -The local effects induced by intramuscular inoculations of venons from six species of coral snakes were studied in mice. Venons of Mkrurus nlgrocinctus nigrocinctus, M. n . maspuitensis, M. alleni, M. frontalis, M. aarinkauda and M. surtrtamensis induced prominent myonaxosis which was observal histologically. FYom a morphological point of view all these venons induced a similar pattern of myonecrosis, characterved by a conspiwoua alteration of the intracellular structure . This myotoxic activity was corroboratal by an increase in plasma creative kinase levels 3 hr after i .m . igjection of M. n. nlgnvcinch4,s, M. n . mosrluitensis, M. frontalis and M. carinicvuda venons . M, mipartitus venom did not induce myonaxosis. None of the venons induced edema or hemorrhage at the site of i>ltijection . H . L . and MACFARLANE, W . V ., Eds .) . Oxford : Pergamon Press . Fotn.nRwiv, J ., EwxeR, D ., Kwtet .ssoN, E . and Tfrnsr t= .rs, S . (1976) Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the Australien snake Taipan (Oxyumrrus s. scutellatus) . Isolation, characterization, quaternary structure and~harmacological properties . Eur. J. Blochem. 68, 457. GvnEttxez, J . M . and Bot .wr~os, R . (1981) Polimorfismo cromos6mico intraespecifico en la serpiente de coral Microns nigrocinctus (Ophidia : Elapidae) . Revta viol. trop. 29, 115 . GtmEaxEZ, J : M ., CHAVES, F ., RoJws, E . and Bot.wr~os, R. (1980) Efectos locales inducidos por et veneno de la serpiente coral Microns nigroclnctus en ratdn blanco . Toxirnn 18, 633 .