Isolation and characterization of basic myotoxic phospholipases A 2 from Bothrops godmani (Godman's pit viper) snake venom (original) (raw)

AI-generated Abstract

Two basic myotoxic phospholipases A2, designated as myotoxin I and myotoxin II, were isolated from Bothrops godmani snake venom. Myotoxin I exhibited significant phospholipase A2 activity and anticoagulant properties at low concentrations, while myotoxin II demonstrated very low enzymatic activity and required higher concentrations for anticoagulant effects. Both toxins were found to induce severe myotoxic effects in a mouse model and showed immunological relations to myotoxins from Bothrops asper. Their purification involved ion-exchange chromatography and the study provides insights into the biochemical properties and potential therapeutic implications of these venomic components.

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