Health-related quality of life of female patients with congenital adrenal hyperplasia in Malaysia (original) (raw)
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May gender influence the quality of life in children and adolescents with type 1 diabetes?
Patient Preference and Adherence
Introduction: Appropriate health-related quality of life (HRQOL) in children and adolescents with type 1 diabetes constitutes one of the most important factors that determine treatment effectiveness. There are numerous studies which tackle the issue of the relationship between HRQOL and various clinical and demographic factors, including gender. Therefore, the aim of the present study was to assess HRQOL and identify factors by which it may be affected, with particular emphasis on gender. Material and methods: The study group included 197 girls and boys (13.9±2.33 years old) with a history of type 1 diabetes (>1 year) treated with the use of insulin pumps. PedsQL Diabetes Module 3.0 questionnaire was used in the assessment of HRQOL. Multivariate linear regression with gender as a covariate was used to investigate the relationship between total PedsQL score and selected variables associated with patient characteristics, insulin dosage and the control of glycemia. Moreover, the presence of gender differences was verified in terms of variables which significantly affected HRQOL. Results: Significantly higher results were observed in boys as regards the total PedsQL score (70.8±11.91 vs 62.4±13.91; P<0.001) and individual subscales of the questionnaire (except "Worry"). Regression analysis demonstrated the presence of a significant negative relationship between HRQOL assessment and HbA1c concentrations, WHtR value and the frequency of hypoglycemic episodes. However, it was noted that better HRQOL was observed in boys than in girls, regardless of the quality of the metabolic control of diabetes, regular pattern of adipose tissue distribution and experiencing hyperglycemic episodes. Conclusion: Female gender was an independent factor which adversely affected HRQOL. Other factors which negatively influenced HRQOL included poor metabolic control of diabetes, central distribution of adipose tissue and frequent episodes of hyperglycemia. It seems necessary to focus also on other factors that may potentially influence HRQOL of patients with type 1 diabetes.
Pediatrics International, 2010
Background: The aim of this study was to assess (i) the health-related quality of life (HR-QOL) of primary, junior and high school children with type 1 and type 2 diabetes and to compare it with that of healthy school children; and (ii) to compare the diabetes-related QOL (DR-QOL) and the QOL of parents of children with diabetes, between type 1 and type 2 diabetes in Japan. Methods: Overall, 471 patients aged 9-18 years (368 with type 1 and 103 with type 2 diabetes) and their parents were involved. QOL was assessed using a self-administered questionnaire. Results: The total score for HR-QOL of primary and junior school children with type 1 diabetes was significantly higher than that of those with type 2 diabetes and healthy controls. However, there were no significant differences in high school children. Some subscales regarding HR-QOL were significantly lower for children with type 2 diabetes than for children with type 1 diabetes or healthy controls. The DR-QOL of children with type 1 and type 2 diabetes did not significantly differ. The Family Burden and Family Involvement were significantly greater in parents of children with type 1 diabetes. There were significantly positive correlations between HR-QOL and DR-QOL in both groups. In type 1 diabetes only, there were significant negative correlations between glycated hemoglobin and some subscales of the HR-QOL and QOL of parents of children with diabetes, and weak positive correlation between glycated hemoglobin and Family Burden.
Dovepress, 2022
Background: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases during childhood and adolescence. It threatens the health and endangers life with consequences for the physical and emotional development of the child and adolescent. Our study aimed at determining the health-related quality-of-life (HRQoL) and factors affecting it in children and adolescents with T1DM. Methods: A hospital-based cross-sectional study was conducted among 379 randomly selected children and adolescents, 5-18 years of age, with T1DM on follow-up at endocrine clinics from 25 August to 25 September 2021. PedsQLTM 4.0 generic core scales were used to collect the data. Paired sample t-test was used to compare children's and adolescents' self-reports and caregiver's reports. Bivariable and multivariable linear regression is used to explore to identify significant predictor factors of HRQoL. Results: Total mean score of HRQoL was 88.42±10.82 as reported by the children and adolescents and 82.17±12.65 reported by their primary caregivers. According to self-reports, age (β=−0.197, p=0.028), mothers' educational status (β=0.242, p<0.001), fathers' educational status (β=0.259, p<0.001), fathers' occupation (β=0.170, p=0.038), frequency of insulin administration (β=−0.132, p=0.007), diabetes duration (β=−0.101, p=0.050), and frequency of monitoring of blood glucose (β=0.165, p=0.006) were statistically significant predictors of HRQoL, explaining 21.6% of the variability of total HRQoL scores of children and adolescents (R 2 =0.216, F (21,357)=5.968, p<0.001). Conclusion: Children and adolescents with T1DM in Ethiopia have relatively good HRQoL. Increased age, longer diabetes duration, and insulin administrations of three times per day were associated with decreased HRQoL scores. Educated parents, having an employed father, and frequent blood glucose monitoring were associated with higher HRQoL scores.
Quality of Life Among Children With Type 1 Diabetes Mellitus in Alahsa: A Cross-Sectional Study
Cureus
Background: Diabetes mellitus (DM) is the most common endocrine disease in children, and its annual prevalence is increasing worldwide. Health-related quality of life (HRQoL) is a crucial indicator of chronic illnesses such as DM. This study aimed to assess the HRQoL and determine the associated factors among children and adolescents with type 1 DM in Alahsa region in 2022. Methods: An analytical cross-sectional study was conducted in the DiabeterSA center using the Arabic version of the Pediatric Quality of Life Inventory (PedsQl 3.2). All patients aged 5-16 years and diagnosed with type 1 DM were included in the study. Face-to-face interviews were conducted during the patients' routine visits to the outpatient clinic from September 2022 to January 2023. Result: A total of 254 children aged 5-16 years (mean age: 10.87 ± 2.89 years) were recruited. The mean HRQoL total score reported by the children and adolescents was 72.61 ± 15.36. Older age, higher family socioeconomic status, excellent school performance, and higher parental education level, particularly in mothers, were significantly associated with higher total HRQoL scores. In the regression analysis, male sex (β =-0.157, P = 0.018), older age (β = 0.246, P < 0.001), and excellent school performance (β =-0.290, P < 0.001) were identified as independent predictors of the HRQoL total score. Nearly 19% of the participants achieved glycemic control. Conclusion: The quality of life of children and adolescents with type 1 DM in Alahsa region was relatively good. Increased age, good family economic status, and higher parent education levels positively influenced the participants' quality of life. Therefore, regular evaluation of HRQoL is recommended for children and adolescents with type 1 DM to identify problems and initiate an appropriate intervention for improving child health and the health care system.
Quality of Life of Type 1 Diabetic Indian Children and Adolescents -Cross Sectional Study
https://www.ijhsr.org/IJHSR\_Vol.10\_Issue.2\_Feb2020/IJHSR\_Abstract.01.html, 2020
Background and objectives: Quality of life in Individuals with Type 1 diabetes mellitus (T1DM) especially children and adolescents is affected by multiple factors. Aims and Objectives: To ascertain the factors influencing quality of life in Indian children and adolescents with Type1 Diabetes. Materials and Methods: Forty-six children and young people with T1DM, aged 6−18 years were assessed using Down Quality of Life for young, WHO-5 well-being index, Diabetes treatment satisfaction Questionnaire (DTSQ), Diabetes specific Quality of Life scale, strength and difficulty questionnaire (SDQ). Results: Four of study participants were found to be 16.6±0.6 years, 70% of the study participants belonged to age group of 10-19 years. Mean age at onset of diabetes was 9.9±2.8 years. 83% of patients belonged to upper middle income group and none of the participant belonged to lower socio economic status. Good education levels found in our study participants (65.2% of the patients had studied till high school) and their parents (52% had studied till graduation level). Vitamin D deficiency and Hypothyroidism was reported by 4% of the total patients. It was found that 17% of the study participants were obese. 8% were anaemic and 21% had Vitamin D deficiency. Mean (SE) SDQ Parent Proxy scores were 17.75 (0.8) for total difficulties, 4.97 (0.3) for emotional symptoms, 4.04 (0.3) for conduct problems, 4.84 (0.3) for hyperactivity-inattention symptoms, 3.65 (0.3) for peer relationship problems and 5.96 (0.4) for prosocial behaviours. WHO-5 well-being index indicated presence of Poor well-being (raw score <13) in 17% of patients. Low mood was found in 26 % of the subjects. The mean score of the DTSQ was 32.5±13.8 All the patients reported satisfaction with treatment. Hyperglycemia was perceived by 48% of the participants most of the times. Similarly Perceived frequency of hypoglycaemia was reported to be 30.4%. Interpretation of the score. The mean DAWN QoL score was 35. Almost 50% of patients reported adverse impact on the overall quality of life, as well as individual sub-domains of the scale. Conclusion: Children with recent diagnosis, older age at onset, elevated HbA1c, were identified to have higher prevalence of various psychological and cognitive problems. Hence children and adolescents should be prioritized for behavioral and cognitive evaluation.
Diabetes with permanent changes in a person's lifestyle may influence diabetic adolescent quality of life (QOL) negatively. Studies conducted on diabetic patients are increasingly measuring patient-centered outcomes such as functional status and health-related QOL (HRQOL). The development of a HRQOL questionnaire with an optimal measuring performance provides nurses with a standardized assessment tool in order to determine the impact of the disease on diabetic adolescent girl's activity daily living. This study aimed to develop and assess psychometric properties of "Iranian Diabetic Adolescent Girl's QOL (IRDAGQOL)" questionnaire .
Health-Related Quality of Life of Children and Adolescents With Type 1 or Type 2 Diabetes Mellitus
Archives of Pediatrics & Adolescent Medicine, 2008
Your article is protected by copyright and all rights are held exclusively by IPNA. This eoffprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com". Abstract Background Renal replacement therapies may affect the quality of life of patients and their primary caregivers (PC). Methods This study describes the perception of health-related quality of life (HRQoL) of children/adolescents with CKD stages 4-5, as well as of their PC (n=64), in comparison to healthy peers and their PC (n=129), respectively, based on the Peds QL™ 4.0 and Short Form-36 (SF-36) questionnaires and selected biomarkers.
Research Square (Research Square), 2022
Background: Living with type-I diabetes mellitus (T1DM) presents children and adolescents with various daily challenges associated with disease management, including signi cant lifestyle changes due to intensive therapeutic exogenous insulin regimes, the need for dietary restrictions, regular exercise, and frequent biochemical marker monitoring. This study aimed at determining diabetes related quality of life (DRQoL) and factors in uencing quality of life in Indian children and adolescents with T1DM. Methods: Three hundred seventy-nine randomly selected children and adolescents with T1DM were assessed using Pediatric quality of life inventory 3.2 diabetes module. Mean scores of DRQoL according to sociodemographic factors, and clinical variables were assessed by an independent sample t test, or ANOVA according to the characteristics of analyzed variables. Paired sample t-test was used to compare children's and adolescents' self-report with caregivers' report. Multivariable linear regression was used to identify the signi cant predictors of DRQoL. Result: The total score of the PedsQL Diabetes Module self-report were found to be 83.77±11.11 for the 5-12 years old and 80.27±13.52 for the 13-18 years old. Patients who attended education (β =-0.134, p= 0.013) and mothers of the patients being educated (β=0.300, p<0.001), and having insulin injection by primary care givers (β = 0.136, p=0.050) were positive determinants of DRQoL; while not attending diabetic education (β =-0.129, p=0.014) and an increase in the mean fasting blood sugar (FBS) (β =-0.130, p=0.016) were found to be negative determinants that explain 20.3% of the variability of total DRQoL scores of children and adolescents (R 2 =0.203, F(20,312)= 5.225, p<0.001). Conclusions: the quality-of-life score for children and adolescents with T1DM in Ethiopia was not su ciently good. The educational status of patients, mothers' educational status, fathers' occupation, type of individual administering insulin medication, attending diabetes health education and mean fasting blood sugar were found to be determinants of DRQoL.
Health-related quality of life of Pakistani adolescents with type 1 diabetes and their parents
International Journal of Diabetes in Developing Countries, 2020
Objective To assess the health-related quality of life of Pakistani adolescents with type 1 diabetes mellitus and their parents. Methodology This cross-sectional study of adolescents with T1DM and their parents was conducted at Baqai Institute of Diabetology and Endocrinology, a tertiary care hospital, Karachi Pakistan from April 2017 to September 2018. Diabetes Quality of Life for Youths (DQOLY) questionnaire (assess possible problems in six dimensions of impact) and WHO QOL-BREF instrument was used to assess quality of life of adolescents with type 1 diabetes and their parents respectively. The data was entered and analyzed using IBM Statistical Package for Social Sciences version 20. Results Adolescents with T1DM had adverse impact on their quality of life (QOL); overall QOL score was found 20.76 ± 0.83, the maximally reported adverse impact was related to symptoms of diabetes 24.35 ± 1.92 and impact of treatment 24.59 ± 2.12. Females had more adverse impact on QOL score, i.e. 22.49 ± 1.2 (p value = 0.015). Adverse effect on QOL score is strongly correlated with increasing age (p value = 0.006). Overall QOL score of parents/care takers was 56.3 ± 0.98. The worst overall QOL score was noted to be of care takers 53.75 ± 3.4 followed by mothers 54.52 ± 1.25 and fathers 60.56 ± 1.61 respectively (p value = 0.015); the environment domain was associated with statistically significance adverse impact on QOL of mothers (p value = 0.008). Conclusion It is imperative for health care professionals to be aware of the effect of diabetes on QOL as timely screening is important for better health care outcomes.
Quality of life in patients with diabetes mellitus
IMC journal of medical science, 2019
Background and objectives: Diabetes mellitus (DM) perpetually affects the quality of life. This non-communicable lifelong disease usually develops micro and macro-vascular complications affecting vital organs. Thus, it reduces the functional capability of health as assessed by the health-related quality of life (HRQOL) measuring tools. It is not known, how much HRQOL of the diabetic population in Bangladesh is affected. Therefore, the objective of the present study was to estimate the levels of HRQOL of cases with DM attending a tertiary care hospital in Dhaka city. The study considered socioeconomic condition, nutritional status, duration of diabetes and treatment modalities while analyzing the HRQOL. Methods: This study was conducted in a tertiary care hospital in Dhaka city from July 2016 to June 2017. Patients with DM were considered eligible and were recruited. Those who were found to have complications like retinopathy, nephropathy, neuropathy, hypertension and stroke were excluded based on previous investigations. Once selected, the study protocol was described to each of the diabetic patients. If agreed, the participant was interviewed. Short Form health survey questionnaire (SF-36) was used for assessment of HRQOL. The assessment of physical health components included physical function, role physical, body pain, and general health. Mental health components were emotion, vitality and social function. Results: A total of 150 diabetic patients (m/f: 80/70) were included in the study. Comparisons of demographic variables between male and female participants showed no significant difference. As regards HRQOL, physical function score was significantly reduced among those who had diabetes for more than 10 years (p=0.049). General health component was significantly impaired among those who had higher BMI (<30kg/m 2 ; p= 0.016) and postprandial hyperglycemia. Longer duration of DM (>10yrs) and higher BMI significantly reduced components of mental health quality. Conclusion: The study revealed that the overall physical and mental quality of life was significantly affected by longer duration of diabetes, obesity and glycemic status.