Essential role of the CCL2-CCR2 axis in Mayaro virus-induced disease (original) (raw)
Mayaro virus (MAYV) is an emerging arbovirus member of theTogaviridaefamily andAlphavirusgenus. MAYV infection causes an acute febrile illness accompanied by persistent polyarthralgia and myalgia. Understanding the mechanisms involved in arthritis caused by alphaviruses is necessary to develop specific therapies. In this work, we investigated the role of the CCL2/CCR2 axis in the pathogenesis of MAYV-induced disease. For this, WT C57BL/6J and CCR2-/-mice were infected with MAYV subcutaneously and evaluated for disease development. MAYV infection induced an acute inflammatory disease in WT mice. The immune response profile was characterized by an increase in the production of inflammatory mediators, such as IL-6, TNF and CCL2. Higher levels of CCL2 at the local and systemic levels, was followed by significant recruitment of CCR2+macrophages and a cellular response orchestrated by these cells. CCR2-/-mice showed an increase in CXCL-1 levels, followed by a replacement of the macrophage...
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