High iron intake is associated with poor cognition among Chinese old adults and varied by weight status—a 15-y longitudinal study in 4852 adults (original) (raw)

Abstract

Background: High body iron status has been shown to be associated with adverse health outcomes. However, the relation between high body iron status, body mass index (BMI), and cognition is still understudied. Objective: This study aimed to examine the association between iron intake and cognitive function in Chinese adults and tested the interaction effect of iron intake and BMI on cognition. Design: Longitudinal study data from a nationwide sample (n = 4852; age ≥55 y) from the China Health and Nutrition Survey during 1991-2006 were used. Of the participants, 3302 had completed cognitive screening tests in ≥2 surveys. Cognitive function was assessed in

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References (54)

  1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement 2013;9(1):63-75 e2.
  2. Wu YT, Ali GC, Guerchet M, Prina AM, Chan KY, Prince M, Brayne C. Prevalence of dementia in mainland China, Hong Kong and Taiwan: an updated systematic review and meta-analysis. Int J Epidemiol 2018;47 (3):709-19.
  3. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, et al. Dementia prevention, intervention, and care. Lancet 2017;390(10113): 2673-734.
  4. van de Rest O, Berendsen AA, Haveman-Nies A, de Groot LC. Dietary patterns, cognitive decline, and dementia: a systematic review. Adv Nutr 2015;6(2):154-68.
  5. Ozawa M, Shipley M, Kivimaki M, Singh-Manoux A, Brunner EJ. Dietary pattern, inflammation and cognitive decline: the Whitehall II prospective cohort study. Clin Nutr 2017;36(2):506-12.
  6. Belaidi AA, Bush AI. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J Neurochem 2016;139(Suppl 1):179-97.
  7. Agrawal S, Berggren KL, Marks E, Fox JH. Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: a systematic review. Nutr Rev 2017;75(6):456-70.
  8. Logroscino G, Gao X, Chen H, Wing A, Ascherio A. Dietary iron intake and risk of Parkinson's disease. Am J Epidemiol 2008;168(12): 1381-8.
  9. Bao W, Rong Y, Rong S, Liu L. Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis. BMC Med 2012;10:119.
  10. Qizilbash N, Gregson J, Johnson ME, Pearce N, Douglas I, Wing K, Evans SJW, Pocock SJ. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. Lancet Diabetes Endocrinol 2015;3(6):431-6.
  11. Kodl CT, Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev 2008;29(4):494-511.
  12. Kim S, Kim Y, Park SM. Body mass index and decline of cognitive function. PLoS One 2016;11(2):e0148908.
  13. Suemoto CK, Gilsanz P, Mayeda ER, Glymour MM. Body mass index and cognitive function: the potential for reverse causation. Int J Obes (Lond) 2015;39(9):1383-9.
  14. Li M, Hu Y, Mao D, Wang R, Chen J, Li W, Yang X, Piao J, Yang L. Prevalence of anemia among Chinese rural residents. Nutrients 2017;9(3):192.
  15. Qin Y, Melse-Boonstra A, Pan X, Yuan B, Dai Y, Zhao J, Zimmermann MB, Kok FJ, Zhou M, Shi Z. Anemia in relation to body mass index and waist circumference among Chinese women. Nutr J 2013;12(1): 10.
  16. Zhai FY, Du SF, Wang ZH, Zhang JG, Du WW, Popkin BM. Dynamics of the Chinese diet and the role of urbanicity, 1991-2011. Obes Rev 2014;15(Suppl 1):16-26.
  17. Wu YF. Overweight and obesity in China. Br Med J 2006;333(7564):362-3.
  18. Popkin BM, Du S, Zhai F, Zhang B. Cohort profile: the China Health and Nutrition Survey-monitoring and understanding socio- economic and health change in China, 1989-2011. Int J Epidemiol 2010;39(6):1435-40.
  19. Plassman BL, Welsh KA, Helms M, Brandt J, Page WF, Breitner JC. Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up. Neurology 1995;45(8):1446-50.
  20. Lei X, Hu Y, McArdle JJ, Smith JP, Zhao Y. Gender differences in cognition among older adults in China. J Hum Resour 2012;47(4):951- 71.
  21. Ding D, Zhao Q, Guo Q, Meng H, Wang B, Luo J, Mortimer JA, Borenstein AR, Hong Z. Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study. Alzheimers Dement 2015;11(3):300-9, e2.
  22. Yang Y. Chinese food composition table 2004. Beijing (China): Peking University Medical Press; 2005.
  23. Yao M, McCrory MA, Ma G, Tucker KL, Gao S, Fuss P, Roberts SB. Relative influence of diet and physical activity on body composition in urban Chinese adults. Am J Clin Nutr 2003;77(6):1409-16.
  24. Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, Willett WC. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol 1999;149(6): 531-40.
  25. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DR, Schmitz KH, Emplaincourt PO, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000;32: S498-504.
  26. Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm 2010;2010. Available at: https://www.hindawi.com/journals/mi/2010/289645/. A ccessed on 26 October 2018.
  27. Pirpamer L, Hofer E, Gesierich B, De Guio F, Freudenberger P, Seiler S, Duering M, Jouvent E, Duchesnay E, Dichgans M, et al. Determinants of iron accumulation in the normal aging brain. Neurobiol Aging 2016;43:149-55.
  28. Miyake Y, Tanaka K, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, et al. Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci 2011;306(1-2):98-102.
  29. Ortega RM, Requejo AM, Andres P, Lopez-Sobaler AM, Quintas ME, Redondo MR, Navia B, Rivas T. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997;66(4):803-9.
  30. Zhai F, Wang H, Du S, He Y, Wang Z, Ge K, Popkin BM. Prospective study on nutrition transition in China. Nutr Rev 2009;67(Suppl 1):S56- 61.
  31. Chinese Nutrition Society. Chinese DRIs Handbook. Beijing (China): Standards Press of China; 2013.
  32. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11(3):298-300.
  33. Li K, Reichmann H. Role of iron in neurodegenerative diseases. J Neural Transm (Vienna) 2016;123(4):389-99.
  34. Erikson KM, Pinero DJ, Connor JR, Beard JL. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 1997;127(10):2030-8.
  35. Perez VP, de Lima MN, da Silva RS, Dornelles AS, Vedana G, Bogo MR, Bonan CD, Schröder N. Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways. Curr Neurovasc Res 2010;7(1):15-22.
  36. Hernandez Mdel C, Allan J, Glatz A, Kyle J, Corley J, Brett CE, Muñoz Maniega S, Royle NA, Bastin ME, Starr JM, et al. Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936. J Nutr Health Aging 2015;19(1):64-9.
  37. Hagemeier J, Tong O, Dwyer MG, Schweser F, Ramanathan M, Zivadinov R. Effects of diet on brain iron levels among healthy individuals: an MRI pilot study. Neurobiol Aging 2015;36(4): 1678-85.
  38. Daugherty AM, Haacke EM, Raz N. Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults. J Neurosci 2015;35(17):6731-43.
  39. Ayton S, Fazlollahi A, Bourgeat P, Raniga P, Ng A, Lim YY, Diouf I, Farquharson S, Fripp J, Ames D, et al. Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline. Brain 2017;140(8):2112-9.
  40. Ayton S, Faux NG, Bush AI; Alzheimer's Disease Neuroimaging Initiative. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nat Commun 2015;6:6760.
  41. Ayton S, Diouf I, Bush AI; Alzheimer's disease Neuroimaging Initiative. Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study. J Neurol Neurosurg Psychiatry 2018;89(5): 456-60.
  42. Li X, He T, Yu K, Lu Q, Alkasir R, Guo G, Xue Y. Markers of iron status are associated with risk of hyperuricemia among Chinese adults: nationwide population-based study. Nutrients 2018;10(2):191.
  43. Liu M, Wang J, Zeng J, He Y. Relationship between serum uric acid level and mild cognitive impairment in Chinese community elderly. BMC Neurol 2017;17(1):146.
  44. Goozee K, Chatterjee P, James I, Shen K, Sohrabi HR, Asih PR, Dave P, ManYan C, Taddei K, Ayton SJ, et al. Elevated plasma ferritin in elderly individuals with high neocortical amyloid-beta load. Mol Psychiatry 2018;23(8);1807-12
  45. Shi Z, Zhen S, Zhou Y, Taylor AW. Hb level, iron intake and mortality in Chinese adults: a 10-year follow-up study. Br J Nutr 2017;117(4):572- 81.
  46. Gao S, Zhao D, Qi Y, Wang M, Zhao F, Sun J, Liu J. The association between serum ferritin levels and the risk of new-onset type 2 diabetes mellitus: a 10-year follow-up of the Chinese Multi-Provincial Cohort Study. Diabetes Res Clin Pract 2017;130:154-62.
  47. Han LL, Wang YX, Li J, Zhang XL, Bian C, Wang H, Du S, Suo LN. Gender differences in associations of serum ferritin and diabetes, metabolic syndrome, and obesity in the China Health and Nutrition Survey. Mol Nutr Food Res 2014;58(11):2189-95.
  48. Sun L, Zong G, Pan A, Ye X, Li H, Yu Z, Zhao Y, Zou S, Yu D, Jin Q, et al. Elevated plasma ferritin is associated with increased incidence of type 2 diabetes in middle-aged and elderly Chinese adults. J Nutr 2013;143(9):1459-65.
  49. Guo X, Zhou D, An P, Wu Q, Wang H, Wu A, Mu M, Zhang D, Zhang Z, Wang H, et al. Associations between serum hepcidin, ferritin and Hb concentrations and type 2 diabetes risks in a Han Chinese population. Br J Nutr 2013;110(12):2180-5.
  50. Chen T, Ren Y, Liu Y, Long Y, Zhang X, Yu H, Xu J, Yu T, Tian H. Serum gamma-glutamyl transferase, ferritin and the risk of type 2 diabetes in women from a Chinese minority. Diabetes Res Clin Pract 2010;90(3):352-7.
  51. Shi Z, Zhou M, Yuan B, Qi L, Dai Y, Luo Y, Holmboe-Ottesen G. Iron intake and body iron stores, anaemia and risk of hyperglycaemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN). Public Health Nutr 2010;13(9):1319-27.
  52. Luan de C, Li H, Li SJ, Zhao Z, Li X, Liu ZM. Body iron stores and dietary iron intake in relation to diabetes in adults in North China. Diabetes Care 2008;31(2):285-6.
  53. Du S, Zhai F, Wang Y, Popkin BM. Current methods for estimating dietary iron bioavailability do not work in China. J Nutr 2000;130(2):193-8.
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