Antipsychotics and the Risk of Mortality or Cardiopulmonary Arrest in Hospitalized Adults (original) (raw)

OBJECTIVESPrior studies in outpatient and long‐term care settings demonstrated increased risk for sudden death with typical and atypical antipsychotics. To date, no studies have investigated this association in a general hospitalized population. We sought to evaluate the risk of death or nonfatal cardiopulmonary arrest in hospitalized adults exposed to antipsychotics.DESIGNRetrospective cohort study.SETTINGLarge academic medical center in Boston, Massachusetts.PARTICIPANTSAll hospitalizations between 2010 and 2016 were eligible for inclusion. We excluded those admitted directly to the intensive care unit (ICU), obstetric and gynecologic or psychiatric services, or with a diagnosis of a psychotic disorder.INTERVENTIONTypical and atypical antipsychotic administration, defined by pharmacy charges.MEASUREMENTSThe primary outcome was death or nonfatal cardiopulmonary arrest during hospitalization (composite).RESULTSOf 150 948 hospitalizations in our cohort, there were 691 total events (5...