Fallacious Carcinoma- Spindle Cell Variant of Squamous Cell Carcinoma (original) (raw)

Spindle Cell Carcinoma of the Oral Cavity: A Case Report of a Rare Entity and Review of Literature

World Journal of Dentistry, 2012

Spindle cell carcinoma is a rare and peculiar biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. It consists of sarcomatoid proliferation of pleomorphic spindle cells and squamous cell carcinoma. It is considered potentially aggressive in its biological nature with a high incidence of metastases. We report a case of this tumor with an unusual clinical course. The histogenesis of the spindle cell component is discussed in detail in the review of literature.

Diagnostic Enigma of Spindle Cell Carcinoma of the Oral Cavity- Review of Literature

Acta Scientific Dental Scienecs, 2021

Spindle cell carcinoma is a variant of squamous cell carcinoma which has been reported in oral cavity with different demographic data. Spindle cell carcinoma has been addressed with various terminologies including, "sarcomatoid carcinoma", "collision tumor", "pseudocarcinoma" owing to its varied proposed histogenesis. Spindle cell carcinoma is important to understand due to its perplexing pathological diagnosis. The "dedifferentiating" epithelial population into spindle cell morphology leads to overlapping features with other sarcomatous tumors. It is essential to evaluate the lesion and attain a proper diagnosis for better treatment and clinical outcomes. Thus, in this review published literature and reported cases has been presented to understand such aggressive lesion with importance of using diagnostic techniques such as immunohistochemistry to understand the pathogenesis.

Oral Spindle Cell Carcinoma –Diagnosis Based on Immunohistochemical Interpretation

Case Report, 2021

Abstract Spindle Cell Carcinoma (SpCC) is a biphasic tumor. They are proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. It is a rare tumor which is infrequently observed in head, neck and in the aerodigestive tract. The tumor is aggressive and shows high frequency of recurrence and metastasis. It is an aggressive variant of squamous cell carcinoma which resembles a true sarcoma. It is a proliferation of spindle cells and squamous cells. For confirmation of diagnosis, immunohistochemistry is used. A Rare case of spindle cell squamous cell carcinoma in a 61 years old male in the tongue.The patient reported of rapidly growing lesion from six months with pain severe pain, dysphagia and difficulty in swallowing patient had history of chewing tobacco from past 35 years. Keywords: Spindle Cell Variant, Biphasic tumor, Head and Neck, Pseudocarcinoma, Sqamous cell, Dysplastic.

Diagnostic Dilemma – Oral Squamous Cell Carcinoma

2019

Incidence of oral cavity cancer is 2.7% and age-standardized rates (ASR, world standard population) is 5.5. The mortality rate is 2.1% and ASR (W) is 2.7 and 5-year prevalence is 3.1% according to International Agency for Research on Cancer, WHO. In India and Asian countries, oral cancer is most common type of malignancy and account for more than 50% of all cancer cases. This finding is generally linked to the high prevalence of a unique smokeless tobacco habit. This article reports a case of osteomyelitis of mandibular jaw which represented as a diagnostic dilemma in regards to the oral cancer.

A Case of Oral Squamous Cell Carcinoma

Acta scientific dental sciences, 2024

The aim of this work is to raise awareness in the dental community regarding the early diagnosis of malignant lesions of the oral cavity. Materials and methods: The study describes the clinical case of a patient referred by his dentist to the Oral Pathology department for a specialist consultation Results: Histological analysis reported a case of oral squamous cell carcinoma (OSCC). Conclusion: An accurate examination of the oral cavity during regular visits to the dentist, combined with the possibility of performing biopsies in the presence of new formations, allows for the timely detection and management of any diseases, making an early diagnosis possible and therefore improving the quality and expectancy of life of patients. The clinical case reported in the following paper will consequently be reported in the Maxillofacial Surgery unit for the removal of the lesion.

Spindle Cell Squamous Cell Carcinoma of the Tongue: A Rare Variant at an Even Rarer Location

Clinical Cancer Investigation Journal

Spindle cell carcinoma (SpCC) is an unusual variant of squamous cell carcinoma (S.C.C.) of the head and neck region. It is a rare biphasic neoplasm. SpCC is an unusual morphological variant of S.C.C. It is characterized by the presence of both carcinomatous as well as sarcomatous component and accounts for 2 to 3% of all the S.C.C.s. Seven years ago, the W.H.O. classification has placed this tumor under the malignant epithelial tumors and called it SpCC. The histogenesis of spindle cells remains controversial and is believed to be monoclonal epithelial neoplasia with a close association with squamous carcinoma cells. Since SpCC is a rare tumor, its histopathological diagnosis is often very complex. Immunohistochemistry (I.H.C.) supports the epithelial nature of this tumor. Both neoplasia components possess immunoreactivity for cytokeratin and vimentin. We are presenting a case of a middle-aged man who was diagnosed with this rare variant at an even rarer location.

Squamous cell carcinoma of the mandibular alveolar ridge

oral health and dental management, 2004

Relative to the incidence of all cancers, oral and oropharyngeal squamous cell carcinomas represent about 3% of the total. The treatment of intraoral squamous cell carcinoma is guided by the clinical stage of the disease and consists of wide surgical excision, radiation therapy, or a combination of sur-gery and radiation therapy. The prognosis for patients with oral squamous cell carcinoma depends on both histological subtype and clinical extent of the tumor. The overall 5-year survival rate for oral squamous cell carcinoma is around 45 to 50%. A 45-year-old male patient was referred to our clinic with a complaint of nonhealing and progressively enlarging ulcer on the right mandibular alveolar ridge. After the lesion had been diagnosed as squamous cell carcinoma with biopsy, it was treated with both surgery and radiation. There was no second primary lesion or a new, separate lesion in the five follow-up years.

Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma

Ecancermedicalscience, 2014

Spindle cell carcinoma (SpCC), a rare, aggressive variant of squamous cell carcinoma (SCC), is characterised by proliferation of epithelial and mesenchymal components. It is important to diagnose this variant of SCC, because of its tendency to recur and early metastasis. It accounts for 1% of all tumours in the oral cavity. In this paper, we have reported a case of SpCC of the tongue in a 65-year-old male who presented with a polypoidal growth over the lateral border of his tongue with a short history of one month. Immunohistochemical expression of cytokeratin was strongly positive in the epithelial component and focally in the spindle cell component. The spindle cell component showed a strong positivity for vimentin.