Comparative study of implantation rate in cleavage embryo transfer vs blastocyst transfer among couples undergoing in vitro fertilization for treatment of infertility (original) (raw)
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Journal of SAFOG
Embryo transfers (ET) on day 2 or day 3 following fertilization have been the standard of practice since the initial days of human in vitro fertilization (IVF). Recent advances in culture media, as well as embryo culture techniques, have prompted in a shift in strategy to day 5 blastocyst transfers following IVF. However blastocyst transfers, although resulting in slightly better pregnancy rate, are known to be associated with certain disadvantages, such as higher costs, higher cycle cancellation rates, and in vitro damage to embryos. Thus we reviewed our results with day 2 and day 3 ETs to see whether outcomes were adequate to justify a return to day 3 embryo transfer policy. Our data shows a 46% clinical pregnancy rate and 1.9% incidence of multiple pregnancy rate with cleavage transfers. Thus in our setting with a lot of poor resource patients, we feel day 2 or 3 transfer provides a good strategy for IVF cycles.
Journal of Assisted Reproduction and Genetics, 2013
Purpose To evaluate the efficacy of blastocyst transfer in women with at least two previously unsuccessful in vitro fertilization-embryo transfer (IVF-ET) attempts. Methods Retrospective analysis of 238 couples (with previous implantation failures) had equal number (two) of cleavage-stage embryos (n =143) or blastocysts (n =95) transferred in the same IVF center. Results The clinical pregnancy rates and live-birth rates were similar in the cleavagestage embryo transfer group and the blastocyst group (35.6 % vs. 40 % and 32.1 % vs. 35.7 %; p >0.05, respectively). Miscarriage rates (9.8 % vs. 10.5 %) and multiple pregnancy rates (15.6 % vs. 23.6 %) did not differ. Although implantation rate was higher with blastocyst transfer than that with day 3 transfer, it did not reach to a statistical significance (24.7 % and 19 %, respectively, p >0.05). Conclusion Blastocyst transfer in ICSI cycles does not yield a better outcome than that obtained with cleavage-stage embryos in women who had unsuccessful IVF attempts previously. Keywords Failed IVF-ET cycle. Blastocyst transfer. ICSI. Multiple implantation failures Capsule Blastocyst transfer in ICSI cycles does not yield a better outcome than that obtained with cleavage-stage embryos in women who had multiple implantation failures.