Parental age is related to the occurrence of cleft lip and palate in Brazilian populations (original) (raw)
Related papers
Parental age in relation to the severity of cleft lip and/or palate
Orthodontics & Craniofacial Research, 2018
Cleft lip and/or palate is considered the most frequent congenital facial anomaly with variations in the incidence among different ethnic groups. 1-5 Several previous studies have investigated the association between parental age and the risk of having a child with a nonsyndromic cleft, 6-9 and there seems to be an association between increased parental age and the risk of having a child with an oral cleft. Although large population studies have compared the parental age of individuals with clefts vs the general population, 7,8 information on parental age related to the severity of the cleft (complete vs incomplete) in the offspring has been unavailable. This study included a smaller but consecutive population sample for which this information is available. In addition, the study investigates whether an association between parental age and the risk of having a child with a cleft depends on an increased age of only one or both parents. It is hypothesized that: (a) there is no influence of parental age on the severity of the cleft, (b) parental age has no influence on the relative incidence of left-and right-sided clefts.
Parent??s Age and the Risk of Oral Clefts
Epidemiology, 2005
Background-Some malformations are clearly associated with older maternal age, but the effect of older age of the father is less certain. The aim of this study is to determine the degree to which maternal age and paternal age independently influence the risk of having a child with oral clefts.
Influence of Parental Exposure to Risk Factors in the Occurrence of Oral Clefts
Journal of Dentistry, 2020
Statement of the Problem: Non-syndromic cleft lip and palate are the most frequent craniofacial abnormalities in humans. The genetic, environmental and behavioral factors involved in this malformation must be clarified in different parts of the globe in the view of implementing preventive measures. Purpose: To analyze the influence of parental exposure to risk factors on the occurrence of oral clefts. Materials and Method: A case-control study was conducted with 150 mothers of oral cleft children paired by the children’s gender to 300 mothers of children without congenital anomalies from Mato Grosso, Brazil, for the study of the variables: gender and race/color of the children; parental educational level; age; number of pregnancies; prenatal care; obesity; stress; diabetes; hypertension; use of medications, alcohol and illicit drugs; smoking and exposure to ionizing radiation during the first trimester of pregnancy. The results were analyzed in relation to the chances possibility of...
Parental Age and the Risk of Cleft Lip and Palate in a Nigerian Population - A Case–Control Study
Annals of Maxillofacial Surgery, 2020
Introduction: Orofacial clefts are one of the most common congenital malformations in the facial region. Older maternal or paternal age presents higher odds of a child with an orofacial cleft. The objective of the study was to assess the association between parental age and risk of orofacial cleft. Materials and Methods: This was a case–control study among 110 parents of children with orofacial cleft (case group) and 110 parents of children without orofacial cleft (control group). Information on maternal age, paternal age, and type of orofacial cleft in the children were obtained. The results were analyzed using descriptive statistics, Chi-square analysis, and bivariate logistic regressions to measure the association between parental age and orofacial cleft. The value of P was <0.05, with a 95% confidence interval (CI). Results: Information on 219 children (109 cases and 110 controls) was analyzed, of which 52% were females. One respondent from the case group withdrew from the st...
Maternal age and oral clefts: A reappraisal
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts. Study design. A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed. Results. No association between increased maternal age and isolated oral clefts was found. Conclusion. Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.
Jurnal Plastik Rekonstruksi
Background: Cleft lip and palate (CL/P) is one of the most common congenital anomalies with the prevalence of 1 case for every 1000 birth. The purpose of this study is to evaluate the association between paternal and maternal age to the incidence of cleft lip with or without cleft palate.Methods: This case-control study compares data of 74 cleft lip patients who was enrolled in Gentur Cleft Foundation Foundation year 2013 to 2015 compared to those of 86 normal children. Paternal and maternal age were categorized and compared to reference age (25-29 years old). Binary logistic regression was used to assess the interaction between paternal and maternal age adjusted to several confounding factors. Results: Paternal age (PA) 18-24 year has OR 9.12 (95% CI = 2.2-36.7), PA 30-34 has OR 2.74 (95% CI =1.2-5.9), PA 35-48 has OR 5.82 (95% CI = 2.2-15.67) compared to those in the 25-29 years category. Maternal age (MA) 18-24 year has OR 4.385 (95% CI = 1.86-10.36), MA 35-48 has OR 6.58 (95% CI...
Relationship Between Parental Age and Severity of Orofacial Clefts
bioRxiv, 2021
OBJECTIVES This study aims to investigate the relationship between paternal age, maternal age, and both on the severity of orofacial clefts. DESIGN This was a retrospective study of cases which were subjects clinically diagnosed with non-syndromic cleft lip and/or palate (CL/P). Data was obtained from the AFRICRAN project database on Nigerian non-syndromic orofacial cleft cases. SETTING The samples for cases in this study were obtained at the Cleft clinic of Oral and Maxillofacial surgery at the Lagos University Teaching Hospital, Lagos. OUTCOME Primary outcome measure is severity of orofacial clefts and secondary outcome measure is to evaluate the effect of parental age in determining the incidence of left or right sided orofacial clefts. RESULTS There is no statistical significant association between type of CL ± P and parental age in young fathers (p=0.93). When old fathers are considered, percentage of complete (more severe) CL ± P cases increases especially in old mothers and t...
Family history and risk factors for cleft lip and palate patients and their associated anomalies
Stomatologija, 2017
Several environmental and genetic issues have been suspected as risk factors for oral clefts; and many studies have been conducted in this regard; however, large socioeconomic impacts of cleft lip and or palate (CL/P) justifies the need for further multifactorial researches. Current study aimed to assess parental risk factors for CL/P and its associated malformations. Hospital records of 187 consecutive syndromic and non-syndromic children with cleft lip and or palate (103 boys and 84 girls) with a mean age of 1.7 (SD 2.2) years and 190 consecutive non-cleft children (103 boys and 87 girls) with a mean age of 2.8 (SD 2.2) years formed this study. Parental risk factors and abnormalities and physical problems and anomalies were evaluated in all subjects. Family history of clefts (OR 7.4; 95% CI), folic acid consumption (OR 7.3; 95% CI) and consanguineous marriage (OR 3.2; 95% CI) were quite strongly associated with increased risk of CL/P. In addition, all congenital abnormalities and ...
Annals of International medical and Dental Research, 2018
Background: Aim: To assess prevalence pattern of cleft lip and palate and to assess the etiological risk factors like history of consanguinity, familial tendency and socioeconomic status in children with cleft lip and/or palate. Methods: Case records (N=821) of patients with cleft lip and palate were accessed to collect the data. The following information was collected: Age, Gender, Education, Occupation and Income of the parent, History of consanguinity, Familial tendency and Chief complaint/s. The SPSS software was used for the statistical analysis to do the chi-square test and significance level adopted was 5% (P < 0.05). Results: Orofacial clefting was more common in males and laterality of cleft lip occurred more on the left side. The familial tendency was present only in 3% cases. The history of consanguinity was present in 35.7% cases. The socioeconomic deprivation was prominent in cleft cases and values depicted statistical significance. Conclusion: Higher risk of orofacial clefting was seen in consanguineous relations and in families with socioeconomic deprivation.