The mechanism of DNA double-strand break (DSB) resection in human cells (original) (raw)

The paper discusses the mechanisms underlying DNA double-strand break (DSB) resection in human cells, highlighting the differentiation between nonhomologous end joining (NHEJ) and homologous recombination (HR) repair processes. It emphasizes the importance of precise DSB repair to maintain genomic stability, as improper repair can lead to severe cellular consequences including carcinogenesis. The study details the role of various complexes and factors involved in the resection process, specifically the role of the SOSS1 complex and RPA in mediating DNA resection.