Tumour Grading and Discrimination based on Class Assignment and Quantitative Texture Analysis Techniques (original) (raw)
Related papers
Computerized Medical Imaging and Graphics, 2010
Noise is one of the major problems that hinder an effective texture analysis of disease in medical images, which may cause variability in the reported diagnosis. In this paper seven texture measurement methods (two wavelet, two model and three statistical based) were applied to investigate their susceptibility to subtle noise caused by acquisition and reconstruction deficiencies in computed tomography (CT) images. Features of lung tumours were extracted from two different conventional and contrast enhanced CT image data-sets under filtered and noisy conditions. When measuring the noise in the background open-air region of the analysed CT images, noise of Gaussian and Rayleigh distributions with varying mean and variance was encountered, and Fishers' distance was used to differentiate between an original extracted lung tumour region of interest (ROI) with the filtered and noisy reconstructed versions. It was determined that the wavelet packet (WP) and fractal dimension measures were the least affected, while the Gaussian Markov random field, runlength and co-occurrence matrices were the most affected by noise. Depending on the selected ROI size, it was concluded that texture measures with fewer extracted features can decrease susceptibility to noise, with the WP and the Gabor filter having a stable performance in both filtered and noisy CT versions and for both data-sets. Knowing how robust each texture measure under noise presence is can assist physicians using an automated lung texture classification system in choosing the appropriate feature extraction algorithm for a more accurate diagnosis.
A Gabor Filter Texture Analysis Approach for Histopathological Brain Tumor Subtype Discrimination
ISESCO Journal of Science and Technology, 2017
Meningioma brain tumour discrimination is challenging as many histological patterns are mixed between the different subtypes. In clinical practice, dominant patterns are investigated for signs of specific meningioma pathology; however the simple observation could result in inter- and intra-observer variation due to the complexity of the histopathological patterns. Also employing a computerised feature extraction approach applied at a single resolution scale might not suffice in accurately delineating the mixture of histopathological patterns. In this work we propose a novel multiresolution feature extraction approach for characterising the textural properties of the different pathological patterns (i.e. mainly cell nuclei shape, orientation and spatial arrangement within the cytoplasm). The pattern textural properties are characterised at various scales and orientations for an improved separability between the different extracted features. The Gabor filter energy output of each magnitude response was combined with four other fixed-resolution texture signatures (2 model-based and 2 statistical-based) with and without cell nuclei segmentation. The highest classification accuracy of 95% was reported when combining the Gabor filters energy and the meningioma subimage fractal signature as a feature vector without performing any prior cell nuceli segmentation. This indicates that characterising the cell-nuclei self-similarity properties via Gabor filters can assists in achieving an improved meningioma subtype classification, which can assist in overcoming variations in reported diagnosis.
Texture analysis of aggressive and nonaggressive lung tumor CE CT images
IEEE Transactions on Biomedical Engineering, 2008
This paper presents the potential for fractal analysis of time sequence contrast-enhanced (CE) computed tomography (CT) images to differentiate between aggressive and nonaggressive malignant lung tumors (i.e., high and low metabolic tumors). The aim is to enhance CT tumor staging prediction accuracy through identifying malignant aggressiveness of lung tumors. As branching of blood vessels can be considered a fractal process, the research examines vascularized tumor regions that exhibit strong fractal characteristics. The analysis is performed after injecting 15 patients with a contrast agent and transforming at least 11 time sequence CE CT images from each patient to the fractal dimension and determining corresponding lacunarity. The fractal texture features were averaged over the tumor region and quantitative classification showed up to 83.3% accuracy in distinction between advanced (aggressive) and early-stage (nonaggressive) malignant tumors. Also, it showed strong correlation with corresponding lung tumor stage and standardized tumor uptake value of fluorodeoxyglucose as determined by positron emission tomography. These results indicate that fractal analysis of time sequence CE CT images of malignant lung tumors could provide additional information about likely tumor aggression that could potentially impact on clinical management decisions in choosing the appropriate treatment procedure.
CT texture analysis using the filtration-histogram method: what do the measurements mean?
Cancer Imaging, 2013
Analysis of texture within tumours on computed tomography (CT) is emerging as a potentially useful tool in assessing prognosis and treatment response for patients with cancer. This article illustrates the image and histological features that correlate with CT texture parameters obtained from tumours using the filtration-histogram approach, which comprises image filtration to highlight image features of a specified size followed by histogram analysis for quantification. Computer modelling can be used to generate texture parameters for a range of simple hypothetical images with specified image features. The model results are useful in explaining relationships between image features and texture parameters. The main image features that can be related to texture parameters are the number of objects highlighted by the filter, the brightness and/or contrast of highlighted objects relative to background attenuation, and the variability of brightness/contrast of highlighted objects. These relationships are also demonstrable by texture analysis of clinical CT images. The results of computer modelling may facilitate the interpretation of the reported associations between CT texture and histopathology in human tumours. The histogram parameters derived during the filtration-histogram method of CT texture analysis have specific relationships with a range of image features. Knowledge of these relationships can assist the understanding of results obtained from clinical CT texture analysis studies in oncology.
Zenodo (CERN European Organization for Nuclear Research), 2022
Traditional histopathology examination remains a serious task in cancer identification and is clinically vital to division the cancer tissues and group them into numerous classes. However, the diagnostic process is subjective, and the variations among technical observers and time consumed are considerable. Reliable, automated cancer detection assistance is currently an increasingly important task in the medical field. This study aims to classify different cancer tumor types. A comprehensive analysis of a new classification technique based on image processing and composition properties was performed. A graphical user interface (GUI) program dedicated to the classification and identification of cancer cell images was developed and created in-house using Matlab package. As a result, the data can improve the diagnostic capabilities of physicians and reduce the time required for precise diagnosis. The average discrimination rate demonstrates the validity of the proposed technique in distinguishing between benign and malignant lesions. This simple procedure is an encouraging application of digital image processing performance in the histopathology field compared with traditional methods. Further investigations in the future may demonstrate a great advantage in the prediction and classification of cell morphology and cancer grading using the computed segmentation technique.
Texture characterization for hepatic tumor recognition in multiphase CT
Biocybernetics and …, 2006
A new approach to texture characterization from dynamic CT scans of the liver is presented. Images with the same slice position and corresponding to three typical acquisition phases are analyzed simultaneously. Thereby texture evolution during the propagation of contrast product is taken into account. The method is applied to recognizing hepatic primary tumors. Experiments with various sets of texture parameters and two classification methods show that simultaneous analysis of texture parameters derived from three subsequent acquisition moments improves the classification accuracy.
Computerized Medical Imaging and Graphics, 2015
Tissue texture is known to exhibit a heterogeneous or non-stationary nature; therefore using a single resolution approach for optimum classification might not suffice. A clinical decision support system that exploits the subbands' textural fractal characteristics for best bases selection of meningioma brain histopathological image classification is proposed. Each subband is analysed using its fractal dimension instead of energy, which has the advantage of being less sensitive to image intensity and abrupt changes in tissue texture. The most significant subband that best identifies texture discontinuities will be chosen for further decomposition, and its fractal characteristics would represent the optimal feature vector for classification. The performance was tested using the support vector machine (SVM), Bayesian and knearest neighbour (kNN) classifiers and a leave-one-patient-out method was employed for validation. Our method outperformed the classical energy based selection approaches, achieving for SVM, Bayesian and kNN classifiers an overall classification accuracy of 94.12%, 92.50% and 79.70%, as compared to 86.31%, 83.19% and 51.63% for the co-occurrence matrix, and 76.01%, 73.50% and 50.69% for the energy texture signatures; respectively. These results indicate the potential usefulness as a decision support system that could complement radiologists' diagnostic capability to discriminate higher order statistical textural information; for which it would be otherwise difficult via ordinary human vision. samples referring to a certain tumour subtype look identical; raising the issue of misclassification. The automated diagnosis system could also assist in overcoming other diagnosis variability-related subjective factors such as, preconception, expectations, relying on diligence, and fatigue, which could cause differences in image perception. Meningiomas can have three grades numbered from I till III, over here we are more concerned with classifying different subtypes within the same grade, which is considered a more challenging task compared to grade classification, as histopathological features tend to become easier to differentiate by the naked eye in the latter compared to the former case.
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology
Normal lung CT texture features have been used for the prediction of radiation-induced lung disease (RILD). For these features to be clinically useful, they should be robust to tumor size variations and not correlated with the normal lung volume of interest, i.e., the volume of the peri-tumoral region (PTR). CT images of 14 lung cancer patients were studied. Different sizes of gross tumor volumes (GTVs) were simulated and placed in the lung contralateral to the tumor. 27 texture features [nine from intensity histogram, eight from the gray-level co-occurrence matrix (GLCM) and ten from the gray-level run-length matrix (GLRM)] were extracted from the PTR. The Bland-Altman analysis was applied to measure the normalized range of agreement (nRoA) for each feature when GTV size varied. A feature was considered as robust when its nRoA was less than the threshold (100%). Sixteen texture features were identified as robust. None of the robust features was correlated with the volume of the PTR. No feature showed statistically significant differences (P < 0.05) on GTV locations. We identified 16 robust normal lung CT texture features that can be further examined for the prediction of RILD.
2016
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Haralick texture features are a well-known mathematical method to detect the lung abnormalities and give the opportunity to the physician to localize the abnormality tissue type, either lung tumor or pulmonary edema. In this paper, statistical evaluation of the different features will represent the reported performance of the proposed method. Thirty-seven patients CT datasets with either lung tumor or pulmonary edema were included in this study. The CT images are first preprocessed for noise reduction and image enhancement, followed by segmentation techniques to segment the lungs, and finally Haralick texture features to detect the type of the abnormality within the lungs. In spite of the presence of low contrast and high noise in images, the proposed algorithms introduce promising results in detecting the abnormality of lungs inmost of the patient...
Brain Tumour Texture Analysis-A Method
Journal of quality in health care & economics, 2021
Computer aided technology is used in biomedical image processing. In biomedical analysis features are extracted and then the proposed method will detect any abnormalities present or not in the system to be considered. In recent days the detection of brain tumour through image processing is made in medical diagnosis. The separation of tumor is made by the process of segmentation. Brain in human is the most complicated and delicate anatomical structure. There are various brain ailments in human but the indication of cancer in brain tumour may be fatal for the human. Brain tumor can be malignant or benign. The neurologist or neurosurgeon wants to know the exact location, size, shape and texture of tumor from Magnetic Resonance Imaging (MRI) of brain before going to the operation of the brain tumour or decided whether operation of removing brain tumour is at all necessary or not. The disease is analyzed since operation may cause death to the patient. Initially they took a chance by prescribing medicines to see whether there is any improvement of the condition of the patient. If the result is not satisfactory then there is no option other than operation of the tumor. Doctors also take an attempt to find the texture of the tumor since it may help them to know the progress of the tumour. In addition to Brain tumor segmentation, the detection of surface of the texture of brain tumor is required for proper treatment. The chapter proposed methods for detection of the progressive nature of the texture in the tumor presence in brain. For this process segmentation of tumor from other parts of brain is essential. In the chapter segmentation techniques are presented before the texture analysis process is given. Finally, comparisons of the proposed method with other methods are analyzed.