Unusual Coexistence of Takayasu's Arteritis and Systemic Lupus Erythematosus in a Woman: A Case Report (original) (raw)
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Takayasu’s Arteritis with Systemic Lupus Erythematosus: A Rare Association
Case Reports in Rheumatology, 2015
We report the case of a 24-year-old nondiabetic, nonhypertensive lady with history of fatigue, dyspnoea and limb claudication. She has been diagnosed with Takayasu’s arteritis. Subsequently she developed rash, alopecia, joint pain, and various other laboratory abnormalities which led to a diagnosis of SLE. Takayasu’s arteritis (TA) rarely coexists with systemic lupus erythematosus (SLE). The absence of specific SLE markers in patients with TA who subsequently develop SLE suggests that the coexistence of these conditions may be coincidental. The antiphospholipid syndrome in patients with SLE may mimic the occlusive vasculitis of TA.
Systemic Lupus Erythematosus with Takayasu’s Arteritis - A Rare Co-existance
Journal of Medicine, 2021
We report the case of a 30-year-old normotensive, nondiabetic lady diagnosed case of Systemic Lupus Erythematosus(SLE); who came with the complaints of limb claudication. After clinical and lab evaluation she was diagnosed as a case of Takayasus Arteritis along with SLE. Though the co- existence of SLE and Takayasu’s Disease is very rare, we should search for the development of arterial occlusive diseases in SLE cases if the patient has got suspicious symptoms. J MEDICINE 2021; 22: 146-149
Takayasu’s Arteritis and Systemic Lupus Erythematosus-A Rare Coexistence
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018
Takayasu arteritis, also known as "pulseless disease" is an inflammatory disease characterized by large caliber artery inflammation. Although tuberculosis and syphilis are known to be associated with Takayasu arteritis, it is rarely found in association with Systemic Lupus Erythematosus (SLE). We report a case of 28-year-old Indian female with SLE, on low dose corticosteroids, she presented with hypertension and developed sudden onset of abdominal pain. She was found to have features suggestive of large vessel vasculitis. The patient was treated with one month of high dose corticosteroids and discharged. She was reviewed, once inflammation subsided and underwent procedure of placement of a self-expandable stent. She had improvement of blood pressure immediate post procedure and reduction of abdominal pain and claudication pain after two weeks of follow up. Although, SLE is known to involve small and medium-sized arteries, large vessel involvement and features of Takayasu arteritis are extremely rare, clinically.
Systemic lupus erythematosus associated with vasculitic syndrome (Takayasu’s arteritis)
Rheumatology International, 2010
The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease. Case presentation: We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and also present a review of literature. The diagnosis of systemic lupus erythematosus was delayed because our patient's symptoms were initially attributed to sickle-cell disease.
Is aorto-arteritis a manifestation of primary antiphospholipid antibody syndrome?
Lupus, 2011
A 23 year old female presented with dyspnea on exertion and absent pulses in the left upper limb. She had prior history of two first trimester abortions and pre-eclampsia with premature delivery. A Doppler examination had revealed left subclavian and axillary artery thrombosis for which she had been given warfarin six months previously. She was admitted and investigated. Patient had low positive aCL IgG antibody, positive antibeta2gp1 antibody, negative lupus anticoagulant and negative ANA. Patient had cardiomegaly and her echocardiography showed severe aortic regurgitation, moderate mitral regurgitation and moderate pulmonary artery hypertension with poor ejection fraction with normal aortic root. A diagnosis of primary antiphospholipid antibody syndrome with valvular involvement with dilated cardiomyopathy was entertained. A CT angiogram of the aorta revealed narrowing and irregularity of the aorta and its multiple branches suggestive of type III Takayasu's arteritis. Temporal relationship suggests development of aorto-arteritis secondary to APS but simultaneous presence of both these disorders in this patient cannot be ruled out. Lupus (2011) 20, 1554-1556.
Systemic lupus erythematosus: Clinical presentations
Autoimmunity Reviews, 2010
Systemic lupus erythematosus is a complex multisystem autoimmune disease that affects 1 in 2000 adult women in the United Kingdom. Lupus affects Afrocaribbeans and South Asians more frequently and more severely than white British. The disease can affect almost any part of the body and is characterised by remission and relapses. It is most common in women of reproductive age but can present at any age from 1 to 90 years and in men, but the diagnosis is probably missed in some men. It is important to distinguish active lupus features due to inflammatory and thrombotic mechanisms from chronic damage and to be aware that infection is an important trigger that may co-exist or mimic lupus activity. The disease is associated with a variety of autoantibodies that can help in making the diagnosis. Monitoring the disease is usually done using a clinical disease activity index such as the BILAG index, anti-dsDNA antibodies, C3 and C4 levels. Anti-C1q antibodies may have a role in monitoring the disease and in predicting those at risk of renal involvement or flare. The prognosis depends on the organs involved. There is an increased risk of premature atherosclerosis as a complication of lupus and this and infection are the most common causes of death in lupus patients.
Systemic lupus erythematosus is an autoimmune connective-tissue disorder with a wide range of clinical features, which predominantly aff ects women, especially from certain ethnic groups. Diagnosis is based on clinical assessment supported by investigations, including the fi nding of autoantibodies. Treatments range from antimalarial agents to corticosteroids and immunosuppressive agents. This Seminar draws attention to advances in the epidemiology, genetics, cardiovascular risks, lupus nephritis, CNS disease, the antiphospholipid syndrome, assessment of disease activity and damage, and pregnancy related and quality of life issues. New therapeutic approaches, such as biological agents and mycophenolate mofetil, will also be discussed. Systemic lupus erythematosus is a multisystem, auto-immune, connective-tissue disorder with a broad range of clinical presentations. There is a peak age of onset in young women between their late teens and early 40s and women to men ratio of 9:1. Ethnic groups, such as those with African or Asian ancestry, are at greatest risk of developing the disorder, which can be more severe than in white patients. This disorder is a chronic illness that can be life threatening when major organs are aff ected, but more commonly results in chronic debilitating ill health. Factors such as sunlight and drugs could trigger the disorder, but no one cause has been identifi ed and systemic lupus erythematosus has a complex genetic basis.
Cureus, 2021
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that can affect almost every organ in the body. Its complications can often be fatal. The fatal complications include lupus cerebritis, lupus nephritis, and cardiac manifestations such as pericardial effusion. In this report, we discuss the case of a 23-year-old female who presented with complaints of high-grade fever, seizures, and altered mental state (AMS) and was found to have generalized lymphadenopathy (LAP). Various blood and urine analyses and radiological findings (chest X-ray, MRI of the head) were suggestive of lupus nephritis, lupus cerebritis, massive pericardial effusion, and thrombocytopenia. Her anti-double stranded DNA (anti-dsDNA) antibody was positive, and her pericardial fluid was positive for anti-nuclear antibodies (ANAs). She was administered IV glucocorticoids and phenytoin. She reported improvements in her symptoms gradually for a few days but eventually succumbed to the disease. Although generalized LAP is a rare initial presentation of SLE, it should be included in the differential diagnosis of the disease.
Case Report on Systemic Lupus Erythematosus
Indian Journal of Forensic Medicine & Toxicology, 2020
Background: Systemic Lupus Erythematous (SLE) is a multi-system chronic but often episodic,autoimmune condition defined by widespread inflammation of connective tissues and immune complexmediated vasculitis as well as the involvement of Antinuclear Antibodies.Case Presentation: The 11 years old female patient who was apparently alright 2 months back admittedin “Acharya Vinoba Bhave Rural Hospital Sawangi (M), Wardha,” Maharashtra on date 22/02/2020 withthe chief complaint of high-grade fever on and off since 2 months and facial puffiness since 6 days, ascites,constipation and pain in joints. The patient started experiencing fever 02 months back which was highgrade and she took treatment on an OPD basis but there was no relief. After that she was admitted at GMCChandrapur for the complaint of cough, cold, fever and oral ulcer and symptomatic treatment was given andgot discharged after 12 days. Fever, facial puffiness, pain in knee joints. The patient had undergone variousinvestigatio...