Species-Specific Codon Context Rules Unveil Non-Neutrality Effects of Synonymous Mutations (original) (raw)

Background: Codon pair usage (codon context) is a species specific gene primary structure feature whose evolutionary and functional roles are poorly understood. The data available show that codon-context has direct impact on both translation accuracy and efficiency, but one does not yet understand how it affects these two translation variables or whether context biases shape gene evolution.

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