Ontology-enabled Breast Cancer Characterization (original) (raw)
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Anais do Simpósio Brasileiro de Sistemas de Informação (SBSI)
In a scenario where there is a huge amount of available data sources, the Semantic Web has played a key role in sharing, retrieval, selection, and combination of data organized in various formats. The storage and retrieval of medical images manipulated by systems that support breast cancer detection can take great advantage from the use of such technology. In this paper we present a comprehensive study on ontology-based systems that support the manipulation of medical images related to breast cancer, identifying the main features of each approach.
Information Technology in Bio-and Medical Informatics, 2012
Over the last decade, the advances in the high-throughput omic technologies have given the possibility to profile tumor cells at different levels, fostering the discovery of new biological data and the proliferation of a large number of bio-technological databases. In this paper we describe a framework for enabling the interoperability among different biological data sources and for ultimately supporting expert users in the complex process of extraction, navigation and visualization of the precious knowledge hidden in such a huge quantity of ...
ST-ONCODIAG: A semantic rule-base approach to diagnosing breast cancer base on Wisconsin datasets
Breast cancer is a major terminal disease that occurs largely among females. This disease stems from abnormal mutations in the genes of normal cells, thereby resulting in development of cancerous cells. Though there have being several research breakthroughs in the field of medicine in taming this disease, however, computer aided diagnosis on the other hand has proven very supportive in the quest. Techniques such as Machine Learning (ML) and Medical Expert Systems (MES) algorithms have added impetus to the use of artificial intelligence in detecting and diagnosing breast cancer. While MES may seem promising in machine based diagnostic systems, their accuracy is often impaired by inefficient medical reasoning algorithms employed. This paper therefore seeks to address the limitation of one such reasoning algorithm known as Select and Test (ST). The approach in this paper is to first create an efficient input mechanism that enables the system to read, filter and clean input from datasets. Secondly, semantic web languages (ontologies and rule languages) were used to create a coordinated rule set and a knowledge representation framework was created to aid the reasoning algorithm. As a result, the reasoning structures of ST were modified to accommodate this enhancement. Thereafter, the input generating mechanism was used to transform instances of the databases of Breast Cancer Wisconsin Data set retrieved from UCI Learning Repository. The generated inputs were passed into the improved ST algorithm to diagnose breast cancer in patients captured in the datasets. Experiments were carried out, and result show that 26.60%, 56.17%, and 54.05% were diagnosed of breast cancer in Wisconsin Breast Cancer Database (WBCD), Wisconsin Diagnostic Breast Cancer (WDBC), and Wisconsin Prognostic Breast Cancer (WPBC) respectively.
Computers in biology and medicine, 2017
The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient stratification across health institutions due to omic profiling presents a complex scenario to carry out multi-center clinical trials. This paper presents a standards-based approach to ensure semantic integration required to facilitate the analysis of clinico-genomic clinical trials. To ensure interoperability across different institutions, we have developed a Semantic Interoperability Layer (SIL) to facilitate homogeneous access to clinical and genetic information, based on different well-established biomedical standards and following International Health (IHE) recommendations. The SIL has shown suitability for integrating biomedical knowledge and technologies to match the latest clinical advances in healthcare and the use of genomic information. This genomic data integration in the SIL has ...