Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies (original) (raw)

Alkaloids: A Continuation of Search for Antimalarial Leads

Recently, there has been a resurgence of interests in the isolation and antiplasmodial evaluation of alkaloids from different medicinal plant species. The common heterocyclic moieties associated with bioactivity have continued to appear in the structures of the isolated alkaloids. Interestingly, when these compounds were tested against various strains of Plasmodium falciparum, they proved to demonstrate potent antiplasmodial activities. Herein a number of some alkaloids reported between 2014-2017 have been reviewed in order to serve as an inspiration towards optimizing some leads that could offer new antimalarial drugs.

Antimalarial potential of quinones isolated from plants: an integrative review

Research, Society and Development

Antimalarial treatment is often associated with the resistance developed by Plasmodium which generate ineffective drug treatment. Based on this, the search for therapeutic alternatives is necessary and urgent. This review intends to assess the antimalarial potential of quinones isolated from plants. The search for scientific articles was carried out on the CAPES Journal Portal (PPC), Virtual Health Library (VHL), PUBMED, NCBI and SCIELO, using the following descriptors: quinones and antimalarials. Inclusion criteria were adopted based on studies about quinones isolated from plants and tested against Plasmodium falciparum and Plasmodium berghei. The exclusion criteria were based mainly on articles that tested extracts, fractions and synthesis of quinones obtained from plants and other natural products. A total of 1344 publications were collected for screening (PPC = 5, VHL = 248, PUBMED = 525, NCBI = 462 and SCIELO = 94). From this total, 1280 articles were excluded, with only 64 art...

Antimalarial compounds isolated from plants used in traditional medicine

Journal of Pharmacy and Pharmacology, 2009

Objectives This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given for substances with IC50 values ≤ 11 μM. Key findings Malaria is a major parasitic disease in many tropical and subtropical regions and is responsible for more than 1 million deaths each year in Africa. The rapid spread of resistance encourages the search for new active compounds. Nature and particularly plants used in traditional medicine are a potential source of new antimalarial drugs as they contain molecules with a great variety of structures and pharmacological activities. Summary A large number of antimalarial compounds with a wide variety of structures have been isolated from plants and can play a role in the development of new antimalarial drugs. Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for design...