Part 1: Genetic Variant of Human Acetylcholinesterase Part 2: SV-40 Transformed Cell Lines, for Example COS-1, but Not Parental Untransformed Cell Lines, Express Butyrylcholinesterase (BChE) (original) (raw)

Multidisciplinary Approaches to Cholinesterase Functions, 1992

Abstract

Until now no genetic variant of human acetylcholinesterase has been reported. This enzyme is considered essential to life and it was thought that genetic variants of acetylcholinesterase were incompatible with life. However, we have found a common polymorphism in human acetylcholinesterase, histidine 322 being changed to asparagine, in 5% of ACHE alleles of European and American populations. Furthermore, this genetic variation is associated with the YT blood group. We conclude that the YT blood group antigen is located on red blood cell acetylcholinesterase.

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