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Dermatological Applications of EPR: Skin-Deep or In-Depth?
Electron Spin Resonance Spectroscopy in Medicine, 2018
and Its Appendages as Materials for EPR Measurements Electron paramagnetic resonance (EPR; called also electron spin resonance-ESR) is a physical phenomenon and a base for sophisticated techniques of EPR spectroscopy and imaging. In this chapter we focus on the specificity of this technique when applied to dermatology. As its main potential target reader is probably familiar with the physical phenomenon, we would like to pay most of the attention to the biological and medical specificity of the problem. The detailed or simplified description of the physical phenomenon can be found in the wide spectrum of handbooks and reviews, including [1-3] along with the present book. EPR enjoys recently a growing popularity among physicians-scientists, more and more journals publish reviews, and experimental papers concerning applications of EPR to their specific fields [4-9]. Consequently, we would concentrate on the most recent achievements, inventions, and discoveries devoted to the specific field of dermatology and skin as a specific organ for EPR measurements. A wide collection of respective problems enjoying a slightly longer period of "seasoning" will be found in the available reviews. As an object of EPR measurement, skin is a special organ. It is almost impossible to put the whole organism to the resonant cavity, so as to carry out the in vivo EPR investigations of skin in toto. Being the most outer layer of the body, skin will also be difficult to access with an endoscope or endoscope-associated research equipment (e.g., an endoscope-coupled surface coil [10]), not to mention the putative problems in executing an EPR imaging (EPRI) experiment [11]. Nevertheless, the
A bibliography for New Silk Road Studies after Marx@200.pdf
A bibliography for New Silk Road Studies after Marx@200, 2018
The New Silk Roads are commodities that are designed to facilitate further circulation of commodities. The emerging New Silk Road Studies can learn a few things from the traces left by the study of human social history and, of commodities therein, by Karl Marx (1818-1883). The present bibliography, drafted in the bicentenary of birth of Marx, reflects some of those traces. It has three Parts: Part I: Some relevant traces left in Karl Marx’s bibliographies, personal books, notes, excerpts and texts, for Silk Road Studies; Part II: Contemporary Old Silk Road Studies; and, Part III: Emerging New Silk Road Studies.
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound
Neuropharmacology, 2017
The range of therapeutic treatment options for central nervous system (CNS) diseases is greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent the bloodbrain barrier for drug delivery have been investigated, little clinical success has been achieved. Focused ultrasound (FUS) is a unique approach whereby the transcranial application of acoustic energy to targeted brain areas causes a noninvasive, safe, transient, and targeted opening of the BBB, providing an avenue for the delivery of therapeutic agents from the systemic circulation into the brain. There is a great need for viable treatment strategies for CNS diseases, and we believe that the preclinical success of this technique should encourage a rapid movement towards clinical testing. In this review, we address the versatile applications of FUS-mediated BBB opening, the safety profile of the technique, and the physical and biological mechanisms that drive this process.
Chapter 7. Synthesis and Prospects. In: Health in the Americas
Finkelman J (Coordinator). Aldighieri S, Ault SK, Almeida G, Alonso González M, Bernardini D, et al. Chapter 7. Synthesis and Prospects. In: Health in the Americas. Washington DC. Pan American Health Organization 2012. Scientific and Technical Publication No. 636. ISBN 9789275116913 / 9789275316917 / Available English, Spanish and a Portuguese Summary from: http://new.paho.org/saludenlasamericas/index.php?option=com\_content&view=article&id=9&Itemid=14&lang=en
2012
This thesis investigates the geopolitical implications of the recent discoveries in Eastern Mediterranean. The beginning of the paper presents an analysis of the notion of energy security and provides a theoretical framework, according to which international relation theories approach energy security issues. We follow the traditional tripartite division: realism, liberalism, Marxism as this illustrates the main analytical framework in terms of international energy politics. Then, this paper focuses on gas energy and its prospects, scrutinizing the reasons why natural gas emerged as an important energy source in a carbon constrained world. In light of the new gas discoveries, we analyze the potential conflicts and opportunities for cooperation that have been aroused. Israel, Cyprus, Turkey are key countries in this thesis. The analysis of their interactions is grounded on the neo-realistic perspective, which prioritizes the role of the power and highlights insecurity as a constant feature of international system. Finally, we discuss how recent discoveries affect the political agenda of global actors, driven by economic and security reasons and add a new perspective in the geostrategic dimension of this unstable region.