Preliminary Results of DHEA in Poor Responders in IVF (original) (raw)
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Journal of International Medical Research
Objective The effects of dehydroepiandrosterone (DHEA) supplementation in Saudi Arabian women with poor ovarian response (POR) is presently unknown. The present study aimed to assess the benefits of DHEA supplementation in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Methods This was a prospective case-control study involving 62 women who were diagnosed with POR and underwent IVF/ICSI between January 2012 and June 2016. The positive influence of DHEA in 34 women, compared with 28 women without supplementation, was defined as improvements in the number of oocytes retrieved, the fertilization rate, the number of grade I embryos generated and the pregnancy rate. Results Both groups were evenly matched for age, body mass index and laboratory test parameters. There were statistically significant differences between the groups with and without DHEA supplementation for oocyte yield (6.35 ± 2.41 versus 3.98 ± 3.2), Grade I embryos generated (55% ...
JOMENAS Press, 2021
Backgrounds: Poor ovarian reserve and poor ovarian response present a challenge to fertility doctors and in vitro fertilization (IVF) centers. Delaying childbearing is rising nowadays, contributing considerably to an increase in age-related infertility and the demand for assisted reproductive technologies (ART) treatment. This brings to the infertility clinics many women with a diminished ovarian reserve (DOR) and poor ovarian response (POR) Dehydroepiandrosterone (DHEA) is presented as a miracle-drug and has been reported to improve pregnancy chances in patients with a diminished ovarian reserve and poor ovarian response to fertility treatment. Additionally, DHEA is now utilized by approximately one-third of all IVF centers worldwide. Aim: Our objective was to assess DHEA supplementation's effect on women with a diminished ovarian reserve and poor ovarian response to fertility treatment and to find out potential mechanisms of action of DHEA in infertile women. Therefore, we examined the rationale for using DHEA in poor responders and diminished ovarian reserve patients, selected the relevant studies, presented the data, and addressed its potential action mechanisms.