curcumin hydrogel as a support matrix for enhancing adhesion and proliferation of human adipose-derived stem cells (original) (raw)

This study investigates the creation and characterization of chitosan/gellan gum/β-cyclodextrin/curcumin (CS/GG/β-CD/CU) hydrogels designed to enhance the adhesion and proliferation of human adipose-derived stem cells (ADSCs). The hydrogels were produced through the formation of polyelectrolyte complexes, with optimal conditions being a pH of 6.0 and specific weight ratios. The presence of curcumin within the matrix not only improved the structural integrity and pore formation of the hydrogels but also significantly fostered ADSC attachment and proliferation over a week. This research highlights the potential application of these hydrogels in wound healing and tissue engineering.