Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy (original) (raw)

ISMRM Annual Meeting

Abstract

Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.

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