Diversity and Multispecificity of Autoantibodies Reactive with DNA: Some Evolutionary Implications (original) (raw)

Protides of the Biological Fluids, 1985

Abstract

Autoantibodies reactive with DNA are a feature of many connective tissue diseases, most notably systemic lupus erythematosus (SLE) in which those reactive with double stranded DNA (dsDNA) are thought to be important in the pathogenesis of glomerulonephritis. Antibodies reactive with DNA are not limited to such diseases (reviewed by Stollar, 1981) and are found, for example, associated with cardiomyopathy (Maisch at al., 1979) following cardiac allotransplantation (Staines & Chisholm, to be published) and, moreover, are also found in normal individuals (Datta et al, 1983). They have been most studied in relation to SLE in man and lupus-like diseases in mice. In these, the evidence is strongest for their involvement in serious disease pathology: more intensive research might be expected to reveal their importance elsewhere.

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