Impact of the HIV integrase genetic context on the phenotypic expression and in vivo dynamics of integrase inhibitor resistance mutations (original) (raw)
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The study examines the influence of HIV integrase genetic context on the resistance to the integrase inhibitor raltegravir (RAL). It investigates how differences in the genetic background of integrase alleles affect the phenotypic expression of resistance mutations and their dynamics in patients. Through analysis of patient samples, the research underscores that distinct integrase contexts are critical in determining viral fitness and resistance levels, with specific mutations like N155H and Q148H exhibiting varying impacts on viral characteristics.
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