Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases (original) (raw)
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Lipid Nanocarriers for Hyperproliferative Skin Diseases
Cancers
Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.
Nanostructured lipid carriers: A potential use for skin drug delivery systems
Pharmacological Reports, 2019
Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical application makes searching for safe drug carriers that will provide an expected therapeutic effect of utmost importance. Research into safe drug carriers began with liposome structures, paving the way for work with nanocarriers, which currently play a large role as drug vehicles. Nanostructured lipid carriers (NLC) consist of blended solid and liquid lipids (oils) dispersed in an aqueous solution containing a surfactant. These carriers have many advantages: good biocompatibility, low cytotoxicity, high drug content; they enhance a drug's stability and have many possibilities of application (oral, intravenous, pulmonary, ocular, dermal). The following article presents properties, methods of preparation and tests to assess the quality and toxicity of NLC. This analysis indicates the possibility of using NLC for dermal and transdermal drug application.
REVIEW, 2022
Background: The advanced development of lipid nanocarrier contributes a lot to the domain of therapeutic effectiveness of the drug. However the parameter such as drug loading, drug release, stability, and targeting influence much more towards the limitation of many lipid nanocarriers. The Nanostructured lipid carrier, the second generation of lipid carrier has more promising advantages over others and have tremendous targeting ability to skin for drug administration. Objective: The present review paper focus to understand the different fabrication technique, impact of lipid and surfactant on formulation effectiveness, characterization of formulation, and Crystalinity concept of lipid which have an impact on stability & drug loading. Focus on a parameter such as Transepidermal water loss , skin occlusion, and hydration which determine the ability of the carrier to target the skin. Hence the effectiveness of the drug improved. This review also focused on patents based on Nanostructured lipid carriers. Method of preparation: many methods have been adopted to prepare Nanostructured lipid carriers and among all High-pressure homogenization method is considered as best one.
(Phospho)lipid-based Nanosystems for Skin Administration
Current Pharmaceutical Design, 2015
Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products
Solid Lipid Nanoparticles: A Novel Carrier in Skin Diseases
Abstract: Topical treatment of skin diseases is favourable due to the lower risk of systemic side effects. But however the presence of epidermal lipids on stratum corneum prevents the penetration of actives into the viable skin. Solid lipid nanoparticles (SLN) may be considered as an option for topical treatment of skin diseases. Due to its small particle size, SLN results into the formation of occlusive film on the skin surface. These results into targeted drug delivery, controlled release of actives and occlusion associated with improved skin penetration and skin hydration which makes SLN favourable for topical treatment of skin diseases. Here in this review we mention the potential of SLN in treatment of various skin diseases.
Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery
Advanced Pharmaceutical Bulletin
Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loadin...
Recent Advancements in Topical Anti-Psoriatic Nanostructured Lipid Carrier-Based Drug Delivery
International Journal of Molecular Sciences
Psoriasis is linked with unusual differentiation and hyperproliferation of epidermal keratinocytes that significantly impair the quality of life (QoL) of patients. The present treatment options only provide symptomatic relief and are surrounded by various adverse effects. Recently, nanostructured lipid carriers (NLCs) have emerged as next-generation nanocarriers with better physicochemical characteristics. The current manuscript provides background information on psoriasis, its pathophysiology, existing treatment options, and its limitations. It highlights the advantages, rationale, and mechanism of the permeation of NLCs for the treatment of psoriasis. It further gives a detailed account of various NLC nanoformulations for the treatment of psoriasis. In addition, tabular information is provided on the most relevant patents on NLCs for treating psoriasis. Lastly, light is shed on regulatory considerations related to NLC-like nanoformulations. In the treatment of psoriasis, NLCs disp...
Nanostructure Lipid Carrier (NLC): the new generation of lipid nanoparticles
Nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for targetted drug therapy. In 1980 K. Eric Drexler developed and popularized the concept of nanotechnology. The nanocarriers has became a revolutionary approach. Nanocarriers are at forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicines and research. Nanostructure lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment. A new generation of nanostructured lipid carriers (NLCs) consisting of a lipid matrix with a special nanostructured has been developed. This nanostructure improves drug loading and firmly incorporates the drug during storage. The present review gives insights on the definitions and characterization of NLC as colloidal carriers including the production techniques, stability techniques and suitable formulations. This review paper also highlights mechanism of skin penetration and the importance of NLC in pharmaceutical applications.
NANOSTRUCTURED LIPID CARRIERS: A PROMISING APPROACH FOR TOPICAL DRUG DELIVERY SYSTEM
IJPSM, 2021
Nanostructured lipid carriers (NLCs) are innovative pharmaceutical formulations made up of physiological and biocompatible lipids, as well as surfactants and co-surfactant. The initial generation of lipid nanoparticles was Solid Lipid Nanoparticles (SLN), which had a longer-lasting activity and was better, suited to drug penetration. The NLC is a second-generation lipid nanoparticle designed to alleviate the limitations of SLN, such as limited drug loading capacity and solid lipid polymorphism. Many benefits of topical medication delivery include avoiding first-pass metabolism, focusing active components for a local effect, and patient compliance. When compared to typical topical dose forms, nanoparticles have a greater effect in transporting medications through the skin. The structure, composition, many formulation methods, and characterization of NLCs are all important aspects in formulating a stable drug delivery system, as discussed in this review paper. A variety of approaches are used to make solid lipid nanoparticles and nanostructured lipid carriers, which are discussed in this paper. Lipid nanoparticles have a variety of features that make them suitable for topical usage in cosmetics and medicinal formulations. Because of extensive positive benefits such as skin hydration, skin occlusion, and skin targeting, NLCs have a significant potential in the pharmaceutical market. Skin hydration is important for API topical distribution because it hydrates the skin, which causes the pores to open. Trans epidermal water loss decreases due to the occlusion nature of lipid nanoparticles, softening the skin. It is more suited since it uses biodegradable grade lipid, which does not cause toxicity like polymeric Nano formulations. Actually, because of their biodegradable composition, NLCs are a "Nano safe" carrier that has a lot of potential for overcoming the obstacles of topical distribution.