Late Failing Heart Allografts: Pathology of Cardiac Allograft Vasculopathy and Association With Antibody‐Mediated Rejection (original) (raw)

In heart transplantation, late allograft failure remains a significant concern, largely attributed to complications such as antibody-mediated injury and coronary arteriosclerosis. A multicenter study evaluated heart retransplant patients, revealing that a substantial proportion of failing allografts exhibited signs of unrecognized previous antibody-mediated rejection, associated with severe coronary arteriosclerosis. The findings suggest that routine monitoring may overlook subclinical rejection, emphasizing the need for enhanced diagnostic strategies in transplant medicine.