Emerging Polyomavirus Infections: A New Burden for Transplant Recipients and a New Challenge for Transplant Physicians (original) (raw)

2013

Abstract

Since their discovery back in the '70s, the human Polyomaviruses JCV and BKV have been for long time the only members belonging to the Polyomaviridae family able to infect humans. During the last five years, at least ten other human Polyomaviruses have been discovered with similar structural and genomic characteristics of the progenitors BKV and JCV but with some differences in their tropism and pathogenesis. Generally, the primary exposure to all human Polyomaviruses that probably occurs during the first years of life, is frequently asymptomatic, but is always followed by the establishment of latency in several host's cells or tissues. The molecular and pathogenetic events associated with Polyomaviruses persistence and reactivations are not completely understood, whereas it is clear that viral reactivation is closely related to the host's immunological status. Based on these observations, organ recipients and in particular kidney transplant recipients are at risk of Pol...

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