Solid lipid nanoparticles; as a promising drug delivery method to get greater bioavailability: A review (original) (raw)
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Solid Lipid Nanoparticles-A Breakthrough In Novel Drug Delivery System
Solid lipid nanoparticles (SLNs) are the superseding drug delivery system in the nanotechnology sphere. SLNs has been developed at the beginning of 1990s with potential applications in the field of pharmaceuticals, cosmeceuticals, clinical medicine along with research as a substitute to the traditional colloidal carrier systems such as emulsions, liposomes since they exclude those downsides of the traditional system. SLN s offers a great way for controlled drug delivery and site targeting drug delivery as well. This article gives general information about the solid lipid nanoparticles, their production procedures and characterization. In addition to that, the recent advancements of drug delivery systems using SLNs were reviewed.
Nanotechnology is rapidly expanding research area, encompassing the development of man-made materials in nanometer size range. Nanoscale drug delivery system using various nanomaterials is emerging technology for the rational delivery of many chemotherapeutic agents. Nanoparticles attracted the scientists across many disciplines to engineer many desired properties that might otherwise be incompatible on a single device. Formulation scientists are facing the challenges such as poor solubility and bioavailability of the newly invented drugs. One of the approaches to face the above challenge is to develop the particulate carrier system. Solid lipid nanoparticle or liposphere or nanosphere system is the most feasible particulate carrier system which is an alternative to nanoemulsions, liposomes and polymeric nanoparticles. This system offers added advantages in comparison to other related particulate drug delivery systems. The present review emphasizes on various basic and applied aspects of solid lipid nanoparticles in novel drug delivery system especially techniques involved in their production, characterization and various applications. It also focuses on the drug loading capacity, drug incorporation and factors affecting drug release from this colloidal system.
Solid Lipid Nanoparticles : A Lipid Based Drug Delivery
2014
Solid Lipid Nanoparticles is one of the new types of colloidal drug carrier system. SLN consist spherical particles of nanometer range dispersed in water or aqueous surfactant solution. Due to biodegradable and bioacceptable nature of SLN these are less toxic than polymeric nanoparticles and it also overcomes some disadvantage of traditional colloidal drug carrier system. Preparation methods of SLN like hot & cold homogenisation, ultrasonication, emulsification, supercritical fluid technique are described. Aspect of solid lipid nanoparticles their uptake, route of administration, applications, list of different lipid, surfactant are incorporated. Characterisation of SLN by appropriate method like photon correlation spectroscopy, scanning electron microscopy, differential scanning colorimetry is highlighted.
Applications of Solid Lipid Nanoparticle in Novel Drug Delivery System
British Biomedical Bulletin, 2013
Nanotechnology is rapidly expanding research area, encompassing the development of man-made materials in nanometer size range. Nanoscale drug delivery system using various nanomaterials is emerging technology for the rational delivery of many chemotherapeutic agents. Nanoparticles attracted the scientists across many disciplines to engineer many desired properties that might otherwise be incompatible on a single device. Formulation scientists are facing the challenges such as poor solubility and bioavailability of the newly invented drugs. One of the approaches to face the above challenge is to develop the particulate carrier system. Solid lipid nanoparticle or liposphere or nanosphere system is the most feasible particulate carrier system which is an alternative to nanoemulsions, liposomes and polymeric nanoparticles. This system offers added advantages in comparison to other related particulate drug delivery systems. The present review emphasizes on various basic and applied aspects of solid lipid nanoparticles in novel drug delivery system especially techniques involved in their production, characterization and various applications. It also focuses on the drug loading capacity, drug incorporation and factors affecting drug release from this colloidal system.
A SHORT-TERM REVIEW ON SOLID LIPID NANOPARTICLES
IJPSM, 2022
In recent years, Solid lipid nanoparticles (SLNs) have been given a lot of attention as a potential drug distribution alternative to existing colloidal dispersion technologies. The use of SLNs as a pharmaceutical carrier has gotten a lot of focus in recent years. Nanostructure lipid carriers and SLNs are non-toxic since they are biodegradable. SLNs have various distinct properties in terms of therapeutic uses. SLNs are lipid-based nanocarriers with sizes ranging between 10 to 1000 nanometers. Decomposition of the drug can be protected by the drug entrapped in a lipid, physical stability; controlled drug release and remarkable acceptability are all benefits of SLNs over traditional drug carriers. The capacity to incorporate pharmaceuticals into nanocarriers opens up a new paradigm in drug delivery that could hold enormous promise in terms of improving bioavailability while also allowing for controlled and sitespecific drug delivery. This article covers the manufacture and characterization of SLNs, as well as the administration and medicinal uses.
A Review: Solid Lipid Nanoparticles
2021
Solid lipid nanoparticles (SLN) are one of the most rapidly evolving nanotechnology formulations, with numerous applications in fields such as drug delivery, clinical medicine, research, and a variety of other sciences. SLN are nanometer-sized spherical particles that are dissolved in water or aqueous surfactant solution and treated with lipophilic or hydrophilic drugs. Also improving the solubility and bioavailability of poorly soluble drugs can be done with biodegradable and bio acceptable polymers that can also resolve the harmful effects of traditional drug carriers. The different development strategies and their assessment were the subject of this review report. The major applications of SLNs, primarily targeted drug delivery, are discussed, as are the analytical methods used in SLN evaluations.
International Journal of Applied Pharmaceutics, 2019
Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special consideration has been given to the use of SLNs as a drug carrier in recent years. SLNs are aqueous dispersions in which the colloidal particles consist of solid lipids that are biodegradable. As a result of their physical stability, the protection of the entrapped drug from decomposition, the provision of controlled drug release, and the exceptional acceptability, SLNs have several advantages over other drug carriers. This article focuses on the techniques of SLNs preparation and characterization, the effect of formulation variables on SLNs properties, the routes of administration, and the pharmaceutical applications. The data used for this review was collected by searching on Google Scholar and PubMed using the following keywords during the period from 2010 to date.
Solid lipid nanoparticles are at the forefront of the speedily developing field of nanotechnology with numerous potential applications in drug delivery, clinical medicine and research as well as in other diverse sciences. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. Lipid nanoparticles offer the possibility to develop new therapeutics along with applicability for various routes such as oral, topical and parenteral. It acts as colloidal drug carriers for hydrophilic or lipophilic drugs. SLNs unite the advantages of polymeric nanoparticles, fat emulsions and liposomes. The ability to incorporate drugs into nanocarriers offers an innovative prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting.
A Technical Review: Solid- Lipid Nanoparticle (SLN), Their Characteristics and Their Preparation
Asian Journal of Pharmaceutical Research and Development
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their struc...
A NOVEL REVIEW IN NANOPHARMA TECHNOLOGY-SOLID LIPID NANOPARTICLES
Solid lipid nanoparticles (SLN) are rapidly developing colloidal drug delivery systems in the field of nanotechnology. Due to their unique sizedependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. An incorporation of drugs into these nanocarriers offers drug targeting. Hence, there is a tremendous research is going on SLN toreach the goal of controlled and site specific drug delivery. In this article we focused on advantages, different preparation methods which are suitable for large scale production, evaluation and application of SLNs.