Computational modeling of ultrasound pressures in acoustofluidic channels for enhanced sonoporation (original) (raw)

The Journal of the Acoustical Society of America, 2020

Abstract

Acoustofluidic devices are in development for high-precision cell manipulation and molecular loading applications. In this study, experimental results were compared with computational modeling to characterize the ultrasound pressures within acoustofluidic channels. Acoustofluidic devices were fabricated by integrating PZT transducers into PDMS chips. Viability of Jurkat T cells was measured with MTT assays after acoustofluidic treatment at different ultrasound frequencies between 4.970 and 5.030 MHz. A computational model was implemented using a layered resonator approach to characterize the acoustic pressure profiles within the fluidic channels. The computational results revealed distinct frequencies at which the ultrasound pressures within the channels increased by several orders of magnitude due to constructive interference. Experimental results indicated a significant frequency-dependent difference in cell viability after acoustofluidic treatment (ANOVA p-value = 0.02, n = 10/co...

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