Effect of Sucrose Ester Stearate and Carbopol on Nanoemulgel (original) (raw)

2016

Abstract

1. Introduction Recently, nanoemulsion hydrogel has been highlighted as one of the most promising drug delivery system by reason of their unique ability in combining hydrogel system with nanoemulsion [1]. Hydrogels are polymeric networks with three dimensional structure which have the ability to absorb a great amount of water or biological fluids [2]. Avocado oil has been used as an antioxidant due to the high amount of oleic mono saturated fatty acids in the oil [3]. It also promotes the accumulation of HLD cholesterol that gives health benefits to the cardio vascular system [4]. In addition to that, it is useful as anti- inflammatory agent [5] and in cancer prevention [6]. This study aimed to prepare nanoemulsion hydrogel containing avocado oil for topical application on the skin. 2. Material and Method Avocado oil (Sigma-Aldich, South Africa), Sucrose esters (laureate) (Juhalim, Malaysia), glycerol, and Carbopol (HMBG Chemicals, Malaysia). 3. The results & Discussion The ternary phase diagram constructed and presented in fig 1, was used to aid in finding the concentration range of nano-emulsions components [2]. Sucrose laurate has good emulsification property, which may be due to its excellent miscibility between components in the system. Szuts and Szabo-Revesz; Leong et al., found that nanoemulsion that used high HLB value like sucrose laurate as surfactant has good emulsification properties [7]. 4. Conclusıon In the current investigation, the optimum Avocado oil nanoemulsion was prepared by heat inversion and self- emulsification techniques with a composition (60% w/w oil, 16% w/w Stearate and 24% w/w glycerol). After achieving nanoemulsion, it was mixed with Carbopol and water to produce nanoemulsion hydrogel. The droplets size of nanoemulsions hydrogel were less than 200 nm with PDI below 0.2 and Low negative zeta potential > -30, which indicate that the formulations are stable. Finally, Rheology test for nanoemulsions hydrogel showed an increase with the increase in the oil concentration and the inclusion of Carbopol.

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