Green extraction of Sambucus nigra L. for potential application in skin nanocarriers (original) (raw)

Green Materials, 2020

Abstract

Sambucus nigra L. is a well-known species with a wide range of medicinal properties. In this work, supercritical fluid extracts were obtained from fresh and dried elderberries of S. nigra L.: A (dried berries, ethanol (C2H5OH) absolute), B (dried berries, ethanol 96%), C (dried berries, ethanol 70%) and D (fresh berries, ethanol 96%). Evaluation of the in vitro enzymatic activities and antioxidant activity (AA) of the extracts and a preliminary assessment of their safety were carried out. The most promising extracts were selected for encapsulation in polymeric nanoparticles (NPs). All extracts demonstrated low to moderate AA, and they did not reveal any antimicrobial activity against the bacteria and yeasts tested. No toxic effect in the Artemia salina model was observed. Due to the moderate or good AA, anti-collagenase and anti-elastase activities, A and C extracts were selected and then successfully encapsulated into poly(lactide-co-glycolide) (PLGA) NPs. According to morphologica...

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